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This proposal comprises research efforts to study a dynamic non-stationary friction regime with a variable range of external factors or parameters. This research method considers the development of special non-linear mathematical models for enginetribology including the lubricating oil film thickness as a function of a series of independent parameters in extreme working conditions. These modelin ...

The Future Combat System (FCS) military diesel engine propulsion systems tribological considerations are predicted to be compromised primarily by the temperature capability of the lubricating fluid. Thermal oxidation resulting in lubricant work in rigidcondition breakdown and formation of deposits are typical causes of engine failure at high temperature operating conditions. Work in the Phase I ...

Improving particulate matter (PM) analysis technology for on-vehicle measurements remains a significant challenge. The requirement for accurate and highly precise real-time measurement, capable of on-vehicle applications, is rapidly increasing. Expanding demand for compliance measurements, and assessing and evaluating engine performance development and emergent exhaust aftertreatment technologie ...

Given two closely related pieces of software X and Y, where Y differs from X through a number of small but important (from a security point of view) modifications that were done to Y, the

Early and effective hemodialysis can decrease mortality of trauma patients with acute renal failure. Unfortunately, current technology is not easily deployed in the field or during transport of patients. The Sorbent Hemodialysis (SHD) System now beingdeveloped using technology from Ash Medical utilizes the SORB cartridge to produce and regenerate a small dialysate volume (6 liters). The SHD improv ...

DESCRIPTION (provided by applicant): Research laboratories engaged in the discovery of new drugs must be concerned with more than efficacy. Safety pharmacology testing is mandated by regulatory agencies in the USA and Europe. A recent addition to the tests requested by the United States Food and Drug Administration (FDA) is an assessment of the potential for any new drug, and all of its known m ...

The overall goal of this proposal is the development of the force-plate actometer as an instrument to provide quantitative measurements of rodent behavior, including locomotor activity, tremor, rotational activity and amphetamine-induced focused stereotypies. Unlike video tracking systems, the sampling rate can be varied to accommodate experiments requiring rates above 30 frames/s, and the program ...

DESCRIPTION (provided by applicant): A major limitation to using small injectable particles containing therapeutic drugs for controlled drug delivery is their quick removal from the bloodstream by mononuclear phagocytes mainly in the liver and spleen. Recent advances in how to make biodegradable nanoparticles invisible to such processes (stealth nanoparticles) using polyethylene glycol coatings h ...

DESCRIPTION (provided by applicant): This project will develop a multimedia speech perception assessment and training system designed to improve the speech perception skills of adult hearing-aid users. It is estimated that one in three adults will eventually suffer hearing loss. As the population of the US ages, more and more people will be affected. The key assumption underlying the development o ...