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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A biomarker of aging as a predictor of kidney transplant function

    SBC: HEALTHSPAN DIAGNOSTICS, LLC            Topic: NIA

    ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Fungal Metabolites as Novel Anthelmintics against Soil-Transmitted Helminthes.

    SBC: Mycosynthetix, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): Title: Fungal Metabolites as Novel Anthelmintics against Soil-Transmitted Helminthes Project Summary/Abstract It is estimated that over 2 billion people worldwide are suffering from complications due to infections withsoil transmitted helminthes (STHs), but very little research is being conducted by human health pharmaceutical companies. In the USA, it is estim ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Biosensor Assays for Diagnosis of Chronic HCV Infection

    SBC: ALDERON BIOSCIENCES, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): This Phase I SBIR application is submitted in response to the call by DHHS for new tests for qualitative measurement of HCV RNA for diagnosis of chronic HCV infection in patients. The need is for HCV RNA assays that areas reliable but less expensive and resource-demanding than current molecular assays. The new test proposed for research and development consists ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Cell analysis and immunoassay device for distributed HIV diagnosis and monitoring

    SBC: INDEXUS BIOMEDICAL, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): The goal of this research is to develop a new approach to bring diagnosis and monitoring tests for HIV to the primary care level (primary care provider office, small healthcare clinics and labs, and community health center labs) by introducing a multi-functional cell analysis and immunoassay platform that is portable, low cost and easy to use. It will allow pat ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Evaluation of Novel Cyclophilin D Inhibitors for Mitochondrial Disease Therapy

    SBC: SCYNEXIS, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): Myopathies and other clinical disorders arising from genetic abnormalities of the mitochondrial respiratory chain collectively affect as many as 1 in 8000 individuals, representing in aggregate a significant disease burden, even though the specific underlying genetic lesions are each quite rare. Despite the need for therapeutic strategies to prevent or slow the ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Stem cell therapy for improved fixation of cementless total hip replacements

    SBC: AFFINERGY, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): Through modern surgical advancements, total hip replacements (THR) have become one of the most successful implant procedures to date. Even though long-term success rates are high, the staggering number of THR proceduresper annum (~200,000 in the United States alone) results in thousands of failed implants each year. Most implants fail through aseptic loosening ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Novel and Selective AMPK Activator for the Treatment of Hepatocellular Carcinoma

    SBC: NOVATARG, INC.            Topic: NCI

    Project Summary/Abstract Liver cancer, primarily hepatocellular carcinoma (HCC), accounts for ~662,000 deaths each year and is the third leading cause of death from cancer worldwide. The age-adjusted incidence of HCC tripled between 1975 and 2005 in the US, and primary liver cancer mortality rates have increased faster than mortality for any other tumor type. One- and 3-year survival rates were 36 ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Improving chemotherapy outcomes with proprietary molecules targeting the human mi

    SBC: SYMBERIX, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Although non-pathogenic microbes that reside in our intestines generally provide us with numerous health and digestive benefits, a specific microfloral activity is also responsible for the severe and sometimes deadly gastrointestinal (GI) side effects of certain chemotherapeutic and pain medications. The most dangerous and well-understood example of this commen ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Instrument and Method for Forming Three-Dimensional Ultrasound Images of the Brea

    SBC: OPTOSONICS, INC.            Topic: NCI

    High Definition Ultrasound for Mammography Abstract We propose to develop High Definition Ultrasound (HD-US) based on a hemispherical synthetic aperture and backscattered sonic waves. This configuration will produce direct three-dimensional maps of ultrasound reflectivity of breast tissues, and will display higher signal-to-noise, reduced speckle and greater spatial resolution compared to ultra ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. EQUIP: Elements Quality Improvement Process for Youth Mentoring Programs

    SBC: Innovation Research And Training, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): Utilization of research-based and safety-oriented program practices in the youth development field have been associated with positive youth outcomes, and quality improvement processes designed at increasing the utilization of these types of program practices have, in turn, been shown to improve practices, increase staff retention, and youth outcomes. However, r ...

    SBIR Phase I 2014 Department of Health and Human Services

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