Award Data

This Small Business Innovation Research (SBIR) Phase I project will focus on the development of novel environment-friendly nanoporous materials that can effectively absorb and thus remove arsenic from ground water at a very low cost, while providing a means for the safe disposal of the spent arsenic-containing materials. This will be accomplished by (1) preparing the nanoporous geopolymer material ...

This Small Business Innovation Research (SBIR) Phase I project will develop and implement a novel slurry injection device for applications in chemical mechanical planarization (CMP), a key-enabling technology for integrated circuit (IC) manufacturing. In the most current CMP commercial polishers, the slurry is injected on the pad center area during wafer polishing. As a large amount of fresh slurr ...

This Small Business Innovation Research (SBIR) Phase I project will help develop the first effective therapy for late stage hormone refractory Prostate Cancer (PCa). These late stage tumors rely on the Androgen Receptor (AR) pathway, but do not require androgen. Genetic changes allow tumors to use the pathway but escape the need for the hormone. For these patients current therapy (androgen ablatio ...

This Small Business Innovation Research (SBIR) Phase I project will determine the feasibility of using secure text messages (short messaging service, SMS) for mobile commerce. Mobile commerce - payment and messaging done via a mobile device such as a smartphone - is technically challenging because of the competing requirements of security, ease of use, and cost to implement. For mass market adopti ...

This Small Business Innovation Research (SBIR) Phase II project aims to demonstrate a high-performance spin torque magnetoresistive random access memory (ST-MRAM). ST-MRAM technology promises a powerful combination of non-volatility, high density, high speed, and low power. The major impediment to commercializing ST-MRAM has been that the write current for programming the magnetic tunnel junction ...

DESCRIPTION (provided by applicant): Melanoma is a frequently fatal cancer that, if detected early, is relatively easily cured. This disease is rapidly increasing in frequency and has recently been identified by the National Center for Health Statistics Health Disparities Study as a high profile health disparity. Further it has been noted to occur more frequently now in both young people and Hispa ...

DESCRIPTION (provided by applicant): Poly(ADP-ribosyl)ation is a post-translational modification that plays a central role in the regulation of cell death and DNA repair. PAR serves as a surrogate marker for poly(ADP-ribose) polymerase (PARP) and poly(ADP-ribose) glycohydrolase (PARG), which are being actively pursued as therapeutic targets with several PARP inhibitors already in clinical trials. ...

DESCRIPTION (provided by applicant): This proposal will utilize innovative, technologies to allow below the knee amputees to walk and run using a single powered prosthetic device. Current users of passive prosthetic devices typically expend more energy; have reduced ankle motion and power; and increased gait asymmetry resulting in joint and back pain. Augmenting ankle power with a robotic tend ...

DESCRIPTION (provided by applicant): Low-cost nucleic acid analysis, to detect HIV and HBV, has revolutionized screening of the blood supply. In spite of that new genetic sophistication, traditional blood group typing [ABO, Rh] is still performed, for themost part, via variations upon 80-year-old agglutination testing. Recently, the genetic variation which gives rise to the standard blood groups h ...

DESCRIPTION (provided by applicant): The conditions of diabetes and obesity are a growing public health concern affecting more of the population every year. A large segment of the population is pre-diabetic potentially progressing towards diabetes. Food choices impact all of these health problems. The overall goal of this proposal is to increase resistant starch levels in wheat, a principle part o ...