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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Adaptive Clinical Efficacy Evaluation of ONC201 in Recurrent High Grade Glioma

    SBC: Oncoceutics, Inc.            Topic: 102

    Project Summary We propose a two arm adaptive Phase II clinical trial to evaluate ONCa selective antagonist of the G protein coupled receptorGPCRdopamine receptor domainDRDin recurrent glioblastomaGBMand diffuse midline glioma associated with very poor prognoses and limited treatment optionsDRDis overexpressed in high grade gliomas and controls Akt ERK signaling pathwaysDownstream of target engage ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Development of PathDetect: Algorithms that Utilize Smartphone Sensor Data to Detect Adverse Pathway Conditions

    SBC: Pathway Accessibility Solutions, Inc.            Topic: na

    This project develops PathDetect, a smartphone app with algorithms that passively characterize adverse pathway conditions (APCs) as a wheelchair user traverses pedestrian pathways. As cities work to improve sidewalks and pedestrian walkways, accurate sidewalk assessments can provide important data to address APCs which can have a significant impact on older adults and individuals who use wheelchai ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Finding Human Carriers of Taeniasis to Prevent Neurocysticercois Associated Epilepsy

    SBC: APTAGEN LLC            Topic: ODCDC

    NeurocycsticercosisNCCis a leading cause of adult onset epilepsy in the developing world and an increasing public health concern in the United StatesNCC develops in individuals infected with tape worm Taenia soliumTsoliumHowevermost people are unaware of their infection before neurological symptoms appearthus posing a major risk of transmitting the infectionReliable diagnosis and efficacious treat ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Topic 372: Development and Validation of Canine scFvs for Pre-Clinical Development of Targeted Therapeutics- Moonshot

    SBC: Vetigenics LLC            Topic: NCI

    The goal of this SBIR is to provide proof-of-concept of Vetigenics' canine-derived scFv phage display platform for rapid, cost effective production of highly versatile, canine-derived scFvs. scFvs against CD19, CD3 and CTLA4, three high-value, immunological molecules being targeted by antibody-based strategies in human cancer immunotherapy, will be isolated. Selected scFvs will be sequenced and bi ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 373: Monoclonal Antibodies to RNA-modifications

    SBC: Abzyme Therapeutics, LLC            Topic: NCI

    Post-transcriptional RNA modification is quite complex as there are more than sixty known RNA modifications that occur in thousands of RNAs in eukaryotic cells. A number of these RNA modifications have been shown to influence the development and physiology of the central nervous system (CNS) and to be involved in carcinogenesis. Despite the growing interest in and importance of RNA modifications, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Topic 373: Novel Mass Spectrometry Methods and Research Tools to Map Nucleotide Modifications in Cytosolic Transfer RNAs from Cancer Cells

    SBC: Ribonova Inc.            Topic: NCI

    Chemical modifications play a crucial role in the regulation of biological processes. Protein function is often modulated by tagging with phosphates, sugars, or lipids, while epigenomic marks on DNA or histones can regulate gene expression up or down. One area that lags behind is the mechanistic understanding of the role of RNA chemical modifications, sometimes referred to as the 'epitranscriptome ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Piezoelectric Ring Mounted Oscillated Syringe System for Lower Distress, Lower Force, Laboratory Animal Vascular Access and Injection to Improve Data Quality and Laboratory Animal Welfare

    SBC: ACTUATED MEDICAL, INC.            Topic: 200

    This Fast track SBIR developstestsand commercializes aPiezoelectric Ring Mounted Oscillated Syringe System for Lower DistressLower ForceLaboratory Animal Vascular Access and Injection to Improve Data Quality and Laboratory Animal WelfareThe Oscillated Needle InserterONIis a simple one handedvascular access device that uses a novel vibratory piezoelectric ring to directly apply longitudinal microos ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. An Acoustofluidic Device for Biocompatible Platelet Separation

    SBC: Ascent Bio-Nano Technologies Inc            Topic: NHLBI

    Project Summary The ability to perform platelet separation with a high throughputhigh recovery ratehigh purityand high platelet integrity is extremely important in many biomedical research studies and therapeutic applicationssuch as platelet transfusionsCentrifugation is currently thegold standardlaboratory technique used to obtain platelets from whole bloodHoweverthis current approach for platele ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. A Computer Tool for Aiding in Accurate Assessment of Indeterminate Lung Nodules

    SBC: International Intelligent Informatics Solution Laboratory            Topic: 101

    Low dose CT screeningLDCThas been approved by the Centers for Medicare andampMedicaid ServicesCMSfor Medicare coverageHoweverthe primary problem associated with CT is the high false positivedetectionsThis issue often leads to unpleasant and costly unintended consequencese gfollow up scans and or invasive biopsiesIn this projectwe propose to develop and commercializea novel computer tool to aid in ...

    SBIR Phase II 2018 Department of Health and Human Services
  10. Development of an acoustofluidic-based C.elegans 3D imaging and sorting system

    SBC: Ascent Bio-Nano Technologies Inc            Topic: OD

    Project Summary Drug development has become an extremely expensive and time consuming processIt is for this reason that many efforts are being made to overhaul how potential drugs are brought to marketBy lowering the cost in the developmental and testing phasesthe inflated end costs can be controlledThe use of model organisms as a cheaper explorative method prior to human testing hasand must conti ...

    SBIR Phase I 2018 Department of Health and Human Services

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