Award Data

Rapid Virulence Factor Discovery System (RVFDS) is virulence factor-discovery platform in which all of the genes of a pathogen are expressed generating a random expression library (REL). The REL is then screened for the presence of potential virulence factors with an array of pull-down assays that employ components of the host"s extracellular matrix, mucus, and basement membrane as bait. The hos ...

In this project Optofluidics, Inc. proposes to develop the Molecular Medic a point-of-care device for sample collection, processing, and quantification of blood-borne biomarkers. The technology is based on (1) a finger prick assay, (2) a capillary-driven blood filtration system, (3) a novel"nanofluidic collapse"protein concentration technique and (4) a mutliplexable, reconfigurable, ultrasensiti ...

We propose to develop new acoustic metamaterials (AMMs) using locally resonant regimented structures, suitable for application in Hearing Protector Devices (HPDs), that will act as frequency selective acoustic filter for hearing protection. Our computational simulations conducted in phase I project have demonstrated that significant acoustic attenuation can be achieved in desired frequency ranges ...

Our objective is to provide a semi-automated system to generate and verify scalable, high fidelity, multi-dimensional, social networks with realistic distributional, temporal and spatial characteristics as networks and as event sequences. This enables the user to generate networks varying in size, node attributes, geo-temporal characteristics, consistency with other networks, and reflection of kno ...

Dried blood spot (DBS) analysis has gained recognition in recent years in basic science and clinical diagnostics. This impetus relies upon its numerous advantages over the collection, transport and storage of blood samples obtained by conventional venipuncture. Although there is wide-spread interest in DBS, optimization of sample collection and extraction methods, as well as, the subsequent analys ...

RECENT ADVANCES IN HIGH TEMPERATURE SUPERCONDUCTING (HTSC) THIN FILM TECHNOLOGY ENABLE THE FABRICATION OF LOW-LOSS COMPONENTS THAT WILL IMPROVE THE COST AND PERFORMANCE OF CHANNELIZED RECEIVERS. CHANNELIZED RECEIVERS ARE USED IN SATELLITE TRANSPONDER, ELECTRONIC WARFARE AND ELECTRONICS INTELLIGENCE APPLICATIONS AND ARE COMPRISED OF A GROUP OF NARROW BAND RECEIVERS THAT COVER INDIVIDUAL SLOTS IN A ...

SIGNIFICANT SIMPLIFICATION OF MICROWAVE PHASED ARRAY ANTENNA SYSTEM ARCHITECTURES CAN BE ACHIEVED WITH HTSC DEVICE TECHNOLOGY. ELIMINATION OF THE LOW NOISE AMPLIFIERS (LNAS) CAN BE ACCOMPLISHED THROUGH REPLACEMENT OF THE GAAS PHASE SHIFTERS WITH LOW LOSS HTSC COMPONENTS. A REDUCTION IN COMPLEXITY LOWERS BOTH SYSTEM WEIGHT ANDCOST. KEY TO HTSC TECHNOLOGY INSERTION IN PHASED ARRAY ANTENNAS IS THE DE ...

FERROELECTRICS (FE) HAVE A LARGE COMMERCIAL POTENTIAL AS PIEZOELECTRIC ELEMENTS, DIELECTRICS FOR CAPACITORS, AND IN OPTICAL GUIDED-WAVE DEVICES. MATERIALS PROCESSING HAS LIMITED APPLICATIONS IN MICROELECTRONICS AND PHOTONICS, HOWEVER, AND FEW METHODS ARE CAPABLE OF DEPOSITING HIGH QUALITY THIN FILMS COMPATIBLE WITH STANDARD SI INTEGRATED CIRCUIT PROCESS TECHNOLOGY. METALORGANIC CHEMICAL VAPOR DEPO ...

THE OFFERORS PROPOSE TO EFFECTIVELY INTEGRATE THE USSR TECHNOLOGY FOR MULTIPASS AMPLIFIERS WITH USA TECHNOLOGY FOR HIGH AVERAGE ENERGY LOADING AND STRONG COOLING, TO PRODUCE ADVANCED EFFICIENT SLAB LASER DESIGNS FOR 1 KILOWATT OUTPUT DOWER OPERATION IN BOTH HIGH REP RATE Q-SWITCHED AND CW MODES. SLAB LASER DESIGNS HAVE INTRINSIC ADVANTAGE OVER ROD LASER DESIGNS AND CAN BE SCALED FOR HIGH POWER OUT ...

LIVING ORGANISM THRIVE BY HAVING EVOLVED (1) MECHANISMS OF HIGH EFFICIENCY FOR THE INTERCONVERSION OF ENERGY AND (2) MATERIALS CAPABLE OF EXTRAORDINARY DURABILITY, E.G. THE ELASTIC FIBER OF THE AORTIC ARCH BEING CAPABLE OF SUSTAINING BILLIONS OF STRETCH/RELAXATION CYCLES. THESE PROPERTIES OF HIGH EFFICIENCY AND POTENTIAL DURABILITY ARE COMBINED IN SYNTHETIC ELASTIC PROTEIN-BASED POLYMERS. THIS PRO ...