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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel liver fibrosis test for early detection and classification

    SBC: IMMUNOTOPE, INC.            Topic: NIAAA

    DESCRIPTION (provided by applicant): The overall goal of this application is to develop and validate a potential biomarker based assay to determine if it can be used as a noninvasive test to detect the stage of hepatic fibrosis and to predict fibrosis progression in HIV/HCV co-infected patients. Significant fibrosis and cirrhosis are premalignant conditions that greatly increase the risk of the de ...

    STTR Phase I 2013 Department of Health and Human Services
  2. A Diarylheptanoid Scaffold to Treat Taopathies

    SBC: ALS BIOPHARMA, LLC            Topic: NIA

    DESCRIPTION: We identified the Myrica cerifera (Southern Bayberry) extract using a systematic screen as a potent reducer of the structural protein tau, which accumulates in a group of diseases called the tauopathies . The most prevalent tauopathy is Alzheimer's disease, for which there is renewed interest in the identification of tau- based therapeutic approaches to treat this devastating d ...

    STTR Phase I 2013 Department of Health and Human Services
  3. DC-SIGN Inhibitors for the Treatment of HIV Infection

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): DC-SIGN (dendritic cell specific ICAM-3-grabbing non-integrin), a membrane protein of C-type lectin family, is found in high levels on monocyte-derived DCs, some macrophages, and activated B cells. In vivo, DC-SIGN- positive cells were demonstrated in lymph nodes, tonsils, skin, and the subepithelial region of the cervix. DC- SIGN has been shown to bind to a nu ...

    STTR Phase I 2013 Department of Health and Human Services
  4. New therapeutics for the treatment of Acinetobactor baumannii infections.

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): Acinetobacter are strictly aerobic, non-fermentative Gram-negative bacilli that are of major concern in human health, in particular the species Acinetobacter baumannii. They are responsible for clinically important infections that cause a wide variety of maladies including pneumonia, skin and wound infections, bacteremia and meningitis. In addition, A. baumanni ...

    STTR Phase I 2013 Department of Health and Human Services
  5. Polaris Oncology Survivor Transition (POST) System

    SBC: POLARIS HEALTH DIRECTIONS, INC            Topic: NCI

    DESCRIPTION (provided by applicant): The Institute of Medicine (IOM) strongly recommends that all breast cancer patients who are ending active treatment have a survivorship plan. Such a plan should assist patients in moving back to their primary care physician (PCP), provide advice for reducing risk for cancer recurrence or new cancer development, and address the remaining psychosocial challenge ...

    STTR Phase I 2013 Department of Health and Human Services
  6. Inhibitors of IgH Gene Enhancers for the Treatment of Multiple Myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Multiple Myeloma (MM) is a deadly plasma cell malignancy. Treatment advances have improved clinical outcomes over the past decade, but the disease remains incurable, thus creating a need for new and innovative treatmentoptions. The MM drug pipeline includes several proteasome inhibitors and immunomodulatory agents, and other classes of agents that target signal ...

    STTR Phase I 2013 Department of Health and Human Services
  7. Technology-enabled Type 1 Diabetes Education and Support (T1DES)System

    SBC: POLARIS HEALTH DIRECTIONS, INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Management of Type 1 diabetes requires vigilant monitoring by patients who often encounter numerous barriers that can impede proper management. Barriers can include educational, psychosocial, and support issues. PolarisHealth Directions, a small business, and University of Pennsylvania School of Nursing have partnered to develop the Technology-enabled Type 1 Di ...

    STTR Phase I 2013 Department of Health and Human Services
  8. Implantable construct for architectural control of re-vascularization of ischemic

    SBC: Innolign Biomedical, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Innolign Biomedical has developed an implantable product using novel tissue engineering technologies that spatially direct vascularization and will use the product in the treatment of ischemic conditions. The goal of this Phase I STTR proposal is to establish the feasibility of using this novel templated biomaterial, termed MicroBridge, to treat cardiac ischemi ...

    STTR Phase I 2013 Department of Health and Human Services
  9. CHRiSS: Cardiac Health Risk Stratification System

    SBC: JWMC LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): SUMMARY This project aims to produce and beta-test a clinical decision support application for end- stage heart failure, titled CHRiSS: Cardiac Health Risk Stratification System. It will be designed for patients with progressive heart failure who may eventually become candidates for ventricular assist device (VAD) therapy. The software will be build upon existi ...

    STTR Phase I 2013 Department of Health and Human Services
  10. Nogo Decoy Receptor Therapy for the Treatment of Glaucoma

    SBC: ReNetX Bio, Inc.            Topic: NIMHD

    DESCRIPTION (provided by applicant): The objective of this phase I STTR application is to continue assessment of the relevance and feasibility of Nogo decoy receptor therapy for the treatment of glaucoma. The secondary objective is to obtain pharmacokinetic data important for designing additional preclinical efficacy studies and formulating a drug development plan for glaucoma. Our long term objec ...

    STTR Phase I 2013 Department of Health and Human Services

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