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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. ELECTROSPRAY TANDEM TIME-OF-FLIGHT MASS SPECTROMETER

    SBC: ANALYTICA OF BRANFORD, INC.            Topic: N/A

    THE OVERALL OBJECTIVE OF THIS RESEARCH IS TO CONTINUE TO IMPROVE ELECTROSPRAY IONIZATION MASS SPECTROMETRY (ESPI-MS) FOR THE ANALYSIS OF BIOLOGICAL MACROMOLECULES. AS A METHOD CAPABLE OF DELIVERING EXTREMELY LARGE MOLECULES INTO THE GAS PHASE AS INTACT DESOLVATED MOLECULAR IONIC SPECIES FROM THEIR POLAR SOLVENTS, ESPI-MS HAS BEEN EFFECTIVELY EXPLOITEDIN DETERMINING THE MOLECULAR WEIGHTS OF PEPTIDE ...

    SBIR Phase II 1991 Department of Health and Human Services
  2. PROTEIN PURIFICATION KNOWLEDGE BASE

    SBC: Coact Technologies            Topic: N/A

    RECENT ADVANCES IN BIOTECHNOLOGY AND MOLECULAR BIOLOGY HAVE BROUGHT ABOUT NEW CONCERNS IN PROTEIN PURIFICATION. THE PROTEIN PURIFICATION KNOWLEDGE BASE ADDRESSES SOME OF THESE ISSUES BY PROVIDING NEW COMPUTER-READABLE PROTEIN PURIFICATION DATABASES COUPLED WITH AN EXPERT SYSTEM TO SUGGEST PROTOCOLS FOR PURIFYING NEW PROTEINS. EXPERIMENTAL DATA WILL BE SCANNED, DIGITIZED, AND ANALYZED FOR RELEVANT ...

    SBIR Phase II 1991 Department of Health and Human Services
  3. DEVELOPMENT OF AN EMPLOYEE ASSISTANCE PROGRAM HANDBOOK

    SBC: Consad Research Corp.            Topic: N/A

    THE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A MANUAL FOR THOSE CONSIDERING IMPLEMENTING EMPLOYEE ASSISTANCE PROGRAMS IN THEIR BUSINESS SETTINGS AS WELL AS FOR THOSE INTERESTED IN IMPROVING, EXPANDING, AND/OR EVALUATING EXISTING EAPS. THE SEVERAL PURPOSES OF THE HANDBOOK OF THIS EFFORT WOULD BE: TO EDUCATE BOTH LARGE AND SMALL BUSINESSES ABOUT THE CONCEPT OF EMPLOYEE ASSISTANCE; TO ACQUAINT POTENT ...

    SBIR Phase II 1991 Department of Health and Human Services
  4. COMPUTER-ASSISTED STEREOTAXIC NEUROSURGICAL SYSTEM

    SBC: Corpitechs Inc.            Topic: N/A

    THIS PROJECT WILL DEVELOP A SYSTEM OF COMPUTER SOFTWARE AND HARDWARE BROADLY APPLICABLE TO PROBLEMS OF STEREOTAXIC NEUROSURGERY. A NEUROSURGICAL WORKSTATION WOULD PROVIDE THESURGEON WITH EASY ACCESS TO DATA FROM DIFFERING IMAGE MODALITIES (E.G., CT, MRI, AND PET) TO OPTIMIZE STEREOTAXIC PROCEDURES. IN CONTRAST TO EXISTING SYSTEMS, THE WORKSTATION WOULD EASILY INTEGRATE MULTIPLE IMAGES IN A COMMON ...

    SBIR Phase II 1991 Department of Health and Human Services
  5. IMMUNOASSAY FOR GLYCOALBUMIN WITH MONOCLONAL ANTIBODY

    SBC: EXOCELL, INC.            Topic: N/A

    THIS PROJECT WILL DEVELOP A SIMPLE, SPECIFIC, AND RAPID IMMUNODIAGNOSTIC TEST TO MEASURE THE AMOUNT OF NONENZYMATICALLY GLYCATED ALBUMIN IN HUMAN PLASMA. THE TESTWILL BE AN ELISA CONSTRUCT THAT EMPLOYS A MONOCLONAL ANTIBODY THAT SPECIFICALLY RECOGNIZES GLYCATED ALBUMIN, AN INDEX OF THE AMBIENT BLOOD GLUCOSE CONCENTRATIONS OVER THE PRECEDING 2 TO 3 WEEKS. CLINICAL INVESTIGATIONS HAVE ESTABLISHED TH ...

    SBIR Phase II 1991 Department of Health and Human Services
  6. PRECONCENTRATOR/CI SOURCE FOR QMS OF TRACE GASES IN AIR

    SBC: Extrel Corp            Topic: N/A

    THIS RESEARCH WILL DESIGN AND CONSTRUCT THE PREPROTOTYPE OF AN ULTRASENSITIVE ION SOURCE THAT CAN BE EASILY INTERFACED TO QUADRUPOLE MASS SPECTROMETERS FOR REAL-TIME TRACE CONSTITUENT DETECTION. THE DESIGN WILL BE BASED ON THE COMBINATION OF PRECONCENTRATION AND RECOMBINATION-LIMITED, LOW-PRESSURE AIR CHEMICAL IONIZATION (AIR-CI) CONCEPTS. THE GAIN IN CONCENTRATION OF TRACE CONSTITUENTS GENERALLY ...

    SBIR Phase II 1991 Department of Health and Human Services
  7. NOVEL MAGAIN DRUGS FOR PSEUDOMEMBRANOUS COLITIS

    SBC: GENAERA CORPORATION            Topic: N/A

    THE LONG-RANGE OBJECTIVES OF THIS PROJECT ARE TO (1) IDENTIFY NOVEL DRUG CANDIDATES RELATED TO THE MAGAININ CLASSOF PEPTIDES WITH POTENTIAL ANTIBACTERIAL, ANTIVIRAL, AND ANTI-INFLAMMATORY ACTIVITY THAT HAVE GASTROINTESTINAL (GI)-RELATED APPLICATIONS; AND (2) ADVANCE KNOWLEDGE OF THE ROLE AND MECHANISMS OF ENDOGENOUS MEMBRANE CHANNEL-FORMING PEPTIDES. THE MAGAININS, 21 TO 27 AMINO ACID PEPTIDES ISO ...

    SBIR Phase II 1991 Department of Health and Human Services
  8. CONSTRUCTION OF A 200-MHZ PHASE MODULATION SYSTEM

    SBC: Infrascan, Inc.            Topic: N/A

    CONTINUOUS NEAR-RED LIGHT SPECTROSCOPY FOR EARLY WARNING OF HYPOXIC/ISCHEMIC STRESS HAS THE GREAT ADVANTAGE OF SIMPLICITY AND EFFICACY AS A TREND INDICATOR, ON THE ONE HAND, AND TIME-RESOLVED SPECTROSCOPIC TECHNIQUES IN THE PICOSECOND/NANOSECOND REGIONS GIVE THE EXACT PATHLENGTH TRAVELED BY THE PHOTONS, ON THE OTHER. BY TIME SHARING LIGHT WITH THE APPROPRIATE CHOICE OF WAVELENGTHS, THE ABSOLUTE HE ...

    SBIR Phase II 1991 Department of Health and Human Services
  9. N/A

    SBC: Intersciences Inc.            Topic: N/A

    N/A

    SBIR Phase II 1991 Department of Health and Human Services
  10. N/A

    SBC: Neurocommunication Research            Topic: N/A

    N/A

    SBIR Phase II 1991 Department of Health and Human Services

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