Award Data

THE OVERALL OBJECTIVE OF THIS RESEARCH IS TO CONTINUE TO IMPROVE ELECTROSPRAY IONIZATION MASS SPECTROMETRY (ESPI-MS) FOR THE ANALYSIS OF BIOLOGICAL MACROMOLECULES. AS A METHOD CAPABLE OF DELIVERING EXTREMELY LARGE MOLECULES INTO THE GAS PHASE AS INTACT DESOLVATED MOLECULAR IONIC SPECIES FROM THEIR POLAR SOLVENTS, ESPI-MS HAS BEEN EFFECTIVELY EXPLOITEDIN DETERMINING THE MOLECULAR WEIGHTS OF PEPTIDE ...

RECENT ADVANCES IN BIOTECHNOLOGY AND MOLECULAR BIOLOGY HAVE BROUGHT ABOUT NEW CONCERNS IN PROTEIN PURIFICATION. THE PROTEIN PURIFICATION KNOWLEDGE BASE ADDRESSES SOME OF THESE ISSUES BY PROVIDING NEW COMPUTER-READABLE PROTEIN PURIFICATION DATABASES COUPLED WITH AN EXPERT SYSTEM TO SUGGEST PROTOCOLS FOR PURIFYING NEW PROTEINS. EXPERIMENTAL DATA WILL BE SCANNED, DIGITIZED, AND ANALYZED FOR RELEVANT ...

THE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A MANUAL FOR THOSE CONSIDERING IMPLEMENTING EMPLOYEE ASSISTANCE PROGRAMS IN THEIR BUSINESS SETTINGS AS WELL AS FOR THOSE INTERESTED IN IMPROVING, EXPANDING, AND/OR EVALUATING EXISTING EAPS. THE SEVERAL PURPOSES OF THE HANDBOOK OF THIS EFFORT WOULD BE: TO EDUCATE BOTH LARGE AND SMALL BUSINESSES ABOUT THE CONCEPT OF EMPLOYEE ASSISTANCE; TO ACQUAINT POTENT ...

THIS PROJECT WILL DEVELOP A SYSTEM OF COMPUTER SOFTWARE AND HARDWARE BROADLY APPLICABLE TO PROBLEMS OF STEREOTAXIC NEUROSURGERY. A NEUROSURGICAL WORKSTATION WOULD PROVIDE THESURGEON WITH EASY ACCESS TO DATA FROM DIFFERING IMAGE MODALITIES (E.G., CT, MRI, AND PET) TO OPTIMIZE STEREOTAXIC PROCEDURES. IN CONTRAST TO EXISTING SYSTEMS, THE WORKSTATION WOULD EASILY INTEGRATE MULTIPLE IMAGES IN A COMMON ...

THIS PROJECT WILL DEVELOP A SIMPLE, SPECIFIC, AND RAPID IMMUNODIAGNOSTIC TEST TO MEASURE THE AMOUNT OF NONENZYMATICALLY GLYCATED ALBUMIN IN HUMAN PLASMA. THE TESTWILL BE AN ELISA CONSTRUCT THAT EMPLOYS A MONOCLONAL ANTIBODY THAT SPECIFICALLY RECOGNIZES GLYCATED ALBUMIN, AN INDEX OF THE AMBIENT BLOOD GLUCOSE CONCENTRATIONS OVER THE PRECEDING 2 TO 3 WEEKS. CLINICAL INVESTIGATIONS HAVE ESTABLISHED TH ...

THIS RESEARCH WILL DESIGN AND CONSTRUCT THE PREPROTOTYPE OF AN ULTRASENSITIVE ION SOURCE THAT CAN BE EASILY INTERFACED TO QUADRUPOLE MASS SPECTROMETERS FOR REAL-TIME TRACE CONSTITUENT DETECTION. THE DESIGN WILL BE BASED ON THE COMBINATION OF PRECONCENTRATION AND RECOMBINATION-LIMITED, LOW-PRESSURE AIR CHEMICAL IONIZATION (AIR-CI) CONCEPTS. THE GAIN IN CONCENTRATION OF TRACE CONSTITUENTS GENERALLY ...

THE LONG-RANGE OBJECTIVES OF THIS PROJECT ARE TO (1) IDENTIFY NOVEL DRUG CANDIDATES RELATED TO THE MAGAININ CLASSOF PEPTIDES WITH POTENTIAL ANTIBACTERIAL, ANTIVIRAL, AND ANTI-INFLAMMATORY ACTIVITY THAT HAVE GASTROINTESTINAL (GI)-RELATED APPLICATIONS; AND (2) ADVANCE KNOWLEDGE OF THE ROLE AND MECHANISMS OF ENDOGENOUS MEMBRANE CHANNEL-FORMING PEPTIDES. THE MAGAININS, 21 TO 27 AMINO ACID PEPTIDES ISO ...

CONTINUOUS NEAR-RED LIGHT SPECTROSCOPY FOR EARLY WARNING OF HYPOXIC/ISCHEMIC STRESS HAS THE GREAT ADVANTAGE OF SIMPLICITY AND EFFICACY AS A TREND INDICATOR, ON THE ONE HAND, AND TIME-RESOLVED SPECTROSCOPIC TECHNIQUES IN THE PICOSECOND/NANOSECOND REGIONS GIVE THE EXACT PATHLENGTH TRAVELED BY THE PHOTONS, ON THE OTHER. BY TIME SHARING LIGHT WITH THE APPROPRIATE CHOICE OF WAVELENGTHS, THE ABSOLUTE HE ...

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