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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of the VirtualTAVR system for diagnostics and preventative strategies

    SBC: Dura LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Since the first procedure in there has been an explosive growth in transcatheter aortic valve replacement TAVR Up to date more than TAVR had been performed worldwide Despite the increased global experience with TAVR severe adverse events associated with TAVR have been extensively documented including annulus rupture coronary occlusion para ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Measurement of Beta Cell Death in Diabetes

    SBC: L2 DIAGNOSTICS, LLC            Topic: 200

    DESCRIPTION provided by applicant All forms of diabetes are characterized by the death of insulin producing cells In Type diabetes T D this leads to the reliance on exogenous insulin for survival Death of cells is silent it cannot be detected in vivo until it has progressed to such an extent that metabolic function is impaired The loss of cells has only been assessed by functiona ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Development of PAR2 Inhibitors for the Treatment of Nonalcoholic steatohepatitis

    SBC: OASIS PHARMACEUTICALS, LLC            Topic: NIDDK

    DESCRIPTION provided by applicant Non alcoholic steatohepatitis NASH is characterized by fatty changes in the liver with inflammation and hepatocellular injury that in advanced stages leads to fibrosis and cirrhosis and high mortality rates NASH is frequently associated with other common metabolic abnormalities such as insulin resistance and visceral obesity Liver transplantation is curren ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Brain penetrant Hsp90 inhibitors for Alzheimer's disease

    SBC: YUMA THERAPEUTICS CORPORAITON            Topic: NIA

    DESCRIPTION provided by applicant Neurodegeneration in Alzheimerandapos s disease AD may result from deposition of A as plaques in brain tissue However less effort has been made to elucidate the role of tau containing neurofibrillary tangles NFTs in AD Accumulating evidence suggests that tau containing NFTs is an important component in the initiation and progression of AD and other neu ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Broad-spectrum, orally-bioavailable beta-lactamase inhibitors

    SBC: VenatoRx Pharmaceuticals, Inc.            Topic: R

    DESCRIPTION provided by applicant Broad spectrum orally bioavailable lactam antibiotics play a critical role in the management of human infectious diseases both in the hospital and community settings facilitating exit from the ICU and treatment in the general ward early discharge and or prevention of hospitalization The rapid spread of lactamase driven resistance in Enterobacteriaceae ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Small Molecule Inhibitors of trans-Translation with Broad Spectrum Antibacterial

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Because of the emergence of resistance to known antibiotics there is a critical need for new antibacterial agents especially against Gram negative pathogens trans Translation is a biochemical pathway that is essential to many bacterial species including Neisseria gonorrhoeae Shigella flexneri and Mycoplasma spp A high throughput assay of trans translatio ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Novel Inhibitors Targeting Early Steps of Human Cytomegalovirus Replication

    SBC: MICROBIOTIX, INC.            Topic: R

    DESCRIPTION provided by applicant Human cytomegalovirus HCMV infection is a major cause of morbidity and mortality in immunosuppressed patients especially recipients of solid organ or bone marrow transplants HCMV infection of neonates is associated with deafness mental retardation and mortality Although five anti viral drugs GCV val GCV CDV PFA Foscarnet have been approved and lice ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. TN-LAMP-vax: a Multi-Valent Tree Nut Allergy Immunotherapy

    SBC: Immunomic Therapeutics, Inc.            Topic: R

    DESCRIPTION provided by applicant Extreme reactions to food results in over incidents of anaphylaxis and between deaths in the US each year Allergies to tree nuts TN such as almond cashew hazelnut and walnut are collectively the second most common triggers of anaphylaxis behind peanut An estimated million Americans are allergic to TNs with many impacted by exposure to ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Ocular Formulation Development of Innovative Novel Compounds with superior ocular

    SBC: CATALYST, LLC            Topic: N

    DESCRIPTION provided by applicant As anyone who has had an eye injury or even a small foreign object in the eye knows the cornea and surrounding structures are exquisitely sensitive to physical trauma Ocular pain can be agonizing paralyzing and extremely distressing to both the affected person and particularly in the case of pediatric cases family members who may feel powerless to help S ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health

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