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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Novel Antibacterial Agents That Target DNA Replication in Mycobacterium tuberculo

    SBC: Achillion Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): Mycobacterium tuberculosis (MTB) is probably the most ubiquitous microbial pathogen in the world today infecting one-third of the total population and causing millions of active tuberculosis (TB) cases each year. The economic costs are substantial and more than one million people die of TB infections each year. Before the arrival of antimicrobial therapy, TB wa ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. A Compact, Efficient Pyrolysis/Oxidation System for Solid Waste Resource Recovery in Space

    SBC: Advanced Fuel Research, Inc.            Topic: X203

    Pyrolysis processing can be used in near term missions for volume reduction, water recovery (drying), stabilization, and enhanced water and oxygen recovery through thermochemical reactions. For longer term missions, the added benefits include production of fuel, multi-purpose carbon, and reactants for in-situ resource utilization (ISRU). The objective of the Phase I SBIR program was to demonstrate ...

    SBIR Phase II 2010 National Aeronautics and Space Administration
  3. Turbine Inlet Gas Temperature Measurement System

    SBC: Advanced Fuel Research, Inc.            Topic: AF083260

    The Air Force is seeking new technology that will provide the means to accurately measure and monitor turbine inlet gas temperature in gas turbine engines, particularly in advanced engines operating at very high temperatures (>3,100 degree F). In Phase I of this program, Advanced Fuel Research, Inc. demonstrated that turbine inlet gas temperature can be determined from non-intrusive measurements ...

    SBIR Phase II 2010 Department of DefenseAir Force
  4. Development of a method to multiplex ChIP-SEQ and ChIP-chip experiments

    SBC: AFFOMIX, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): The immediate objective of our research is to generate a method that will enable researchers to multiplex Chromatin ImmunoPreciptation-Sequencing (ChIP-Seq) analysis in a single Next generation DNA sequencing run. In the to-be-developed method: i) a set of antibodies directed against specific DNA-binding proteins are uniquely bar-coded with a DNA 'ZipCode;' ii) ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. High-throughput screening and identification of scFv antibodies against glycosyla

    SBC: AFFOMIX, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): The specific goal of this proposal is to develop a high-throughput method to identify scFv antibodies that recognize post-translationally modified proteins. We propose to complete a proof-of-concept for a new type of affinity screening process based on emulsion, secretion, and capture, which we term ESCape . In the proposed phage ESCape method, E. coli transfo ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. A bifunctional antibody screening system for both phage display and yeast two-hyb

    SBC: AFFOMIX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): This is a proposal to establish a proof-of-principle for a vector system to isolate high-affinty antibodies through selective rounds in both yeast and Escherichia coli. Antibodies have quickly become extremely useful as therapeutic medicines to treat a wide-variety of disorders. We propose to develop a means of making the discovery of immunotherapeutics faster ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. Passive Range Estimation from Angle-only Sensor Data (Acq Pointing & Tracking)

    SBC: APPLIED MATHEMATICS INC            Topic: MDA08050

    We propose to adapt angle-only passive ranging methods developed for submarine warfare to the problem of range estimation for missiles using current electro-optical sensor systems in order to provide fire control quality tracking at or near threat burnout to support early intercept. Three methods will be developed: parallax or triangulation ranging; angle rate ranging; and tracker/filter algorith ...

    SBIR Phase II 2010 Department of DefenseMissile Defense Agency
  8. Environmentally Constrained Naval Search Planning Algorithms

    SBC: APPLIED MATHEMATICS INC            Topic: N101048

    The Undersea Warfare Decision Support System (USW-DSS), currently employed by Carrier Strike Groups for integrated command and control and anti-submarine warfare (ASW), uses the Operational Route Planner (ORP) that incorporates a genetic algorithm to define optimal ASW search tracks. This capability does not currently consider route planning and supporting ASW operations in the context of avoiding ...

    SBIR Phase I 2010 Department of DefenseNavy
  9. Development of Magnetostrictive Energy Harvesting of Mechanical Vibration Energy

    SBC: Applied Physical Sciences Corp.            Topic: N10AT020

    Applied Physical Sciences and the University of Maryland propose to develop a magnetostrictive transducer that harvests electrical energy from shipboard machinery while simultaneously suppressing vibration to improve the ship’s stealth characteristics and thereby improving the performance of hull mounted sonar systems. Analysis performed during the Base Effort will provide an initial design spec ...

    STTR Phase I 2010 Department of DefenseNavy
  10. External Pipe Sound Pressure Level Sensor

    SBC: Applied Physical Sciences Corp.            Topic: N10AT016

    Applied Physical Sciences (APS) and the Pennsylvania State University Applied Research Laboratory (ARL/PSU) will collaborate in the development of a novel sensor system to measure the low frequency acoustic pressures within a fluid-filled pipe. The proposed concept improves upon the Navy’s current Array Based Acoustic Measurement (ABAM) system for laboratory characterization of full-scale piping ...

    STTR Phase I 2010 Department of DefenseNavy

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