Award Data

Our objective is to design and build a compact system that provides turnkey readiness for commercial and defense use of SNSPDs. Conventional SNSPDs face several limits that lead to tradeoffs between detection efficiency, bandwidth, dark count rate, jitter and operating temperature, and therefore prevent simultaneous realization of DARPA desired parameters in one device. We propose that amorphous N ...

The broader impact/commercial potential of this project includes applications ranging from peak load shifting, grid buffering for renewable energy input, frequency regulation, and chemical conversions. As the percentage of energy from renewables on the grid increases, energy storage will be essential to stabilize the supply and demand. Currently, 20-40% of wind energy is often stranded due to the ...

The broader impact/commercial potential of this project is in enabling the development of inexpensive miniature pumps that can be integrated with bandages in order to apply negative pressure therapy to wounds. Negative pressure wound therapy (NPWT) is the most commonly prescribed therapy for wounds that do not heal by themselves (i.e. chronic wounds), or to make wounds heal faster. However, a limi ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project can strongly influence the healthcare system. The technology of the proposed project has the potential to make a broader impact by decreasing the risk of performing the bone graft harvesting procedure compared to current methods and consequently increase the number of surgeons who choose to c ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is multi-fold: First, the proposed tripolar concentric ring electrode and instrumentation for acquiring brain signals, tripolar electroencephalography (tEEG), is a platform technology that has a variety of medical and commercial applications. By providing significantly clearer brain signals, ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project results from the development of a new class of graphical-media-design system that lies between today's 2D digital paint systems and 3D computer-aided design systems. This technology will allow architects, engineers, artists, and school children to create compelling 3D experiences directl ...

DESCRIPTION (provided by applicant): Over 34 million people are currently living with HIV/AIDS. Combination antiviral therapies have significantly reduced the morbidity and mortality of the disease; however, there is currently no cure for the disease. Discovery that a naturally occurring variant of CCR5, the delta32 mutation, renders cells resistant to HIV infection has led to efforts by several a ...

Abstract The ability of the immune system to recognize and initiate an immune response to foreign particles such as bacteria and viruses has generated interest in development of particulate vaccine technologies. We are developing an innovative approach toproduce particulate vaccines via layer-by-layer (LbL) fabrication of synthetic microparticles (MP). We have shown that LbL-MP loaded with epitope ...

DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

ABSTRACT The long-term product goal of this project is a small molecule therapeutic for choroidal neovascularization (CNV, the hallmark of wet age-related macular degradation), an abnormal growth of blood vessels in the choroid layer of the eye that results in damage to the retina and consequent blindness. Our lead compound is the natural product sterculic acid, which has been shown to inhibit ...