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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Ex vivo purging strategy for treatment of multiple myeloma

    SBC: Dnatrix, Inc            Topic: NCI

    DESCRIPTION (provided by applicant): The ultimate goal of this application is to develop a novel ex vivo purging method using myxoma virus (MYXV), a rabbit-specific poxvirus, to improve the clinical outcomes in treatment of multiple myeloma (MM). MM is aclonal plasma cell malignancy that has to date resisted essentially all therapeutic strategies. Currently, the standard of care for patients wit ...

    STTR Phase I 2014 Department of Health and Human Services
  2. Screening for Novel CBS Inhibitors for Cancer Therapy

    SBC: CBS THERAPEUTICS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Recent studies of the applicants support the role of the endogenous gaseous biological mediator hydrogen sulfide (H2S) in colorectal cancer: selective upregulation of cystathionine-b-synthase (CBS) and the subsequent production of H2S in colonic cancer cells serves as a pro-survival factor by stimulating tumor cell bioenergetics, growth, proliferation, migratio ...

    STTR Phase I 2014 Department of Health and Human Services
  3. Novel Pharmacotherapeutic Bioadhesive Patch for Oral Ulcerations

    SBC: POST OAK PHARMACEUTICALS, INC.            Topic: NIDCR

    Project Summary Oral ulceration is one of the most commonly encountered oral diseases, with an estimated prevalence of 4% in the USA. Managing large or multiple ulcers that are caused by diseases of unknown etiology, such as erosive lichen planus or aphthous ulcers which affect 25% of the population worldwide, is also a challenge to dentists and specialists. Ulceration of the oral mucosa can caus ...

    STTR Phase I 2014 Department of Health and Human Services
  4. A New MicroRNA-1291 Replacement Therapy for Pancreatic Cancer Disease

    SBC: MIRNA THERAPEUTICS, INC.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. There is a clear need for more effective therapies to treat deadly pancreatic cancer disease. MicroRNAs (miRNA or miR) are a large group of short, noncoding RNAs that control posttranscriptional gene expression in human cells, and there is increasing evidence for the exi ...

    STTR Phase I 2014 Department of Health and Human Services
  5. High Throughput Manufacturing of Monodispersed Nanoparticles for Biomedicine

    SBC: CHEMTOR, L.P.            Topic: NIA

    DESCRIPTION (provided by applicant): This Phase I Small Business Technology Transfer (STTR) project focuses on the development of a new platform manufacturing process for large-scale preparation of monodispersed polymeric nanoparticles (NPs) suitable for biomedical applications through the use of a large-scale fiber fluidic system. Although laboratory processes for reproducible synthesis of polyme ...

    STTR Phase I 2014 Department of Health and Human Services
  6. R3: A Smart Attachment for Improving Adherence and Usage of Metered Dose Inhalers

    SBC: Cognita Labs, LLC            Topic: NIDA

    DESCRIPTION (provided by applicant): Respiratory illnesses continue to be on the rise1-4, in particular, COPD alone impacts nearly 210 million globally 6. Metered Dose Inhaler (MDI) is the most common mechanism to deliver medicine, and is used by the patients for both maintenance and rescue medications. It is well established that regular use of the medications minimizes long-term damage to the lu ...

    STTR Phase I 2014 Department of Health and Human Services
  7. EKO Approach To Find Small Molecules That Perturb Protein Protein Interaction

    SBC: Small Molecules PPI Mimics, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): One of the major new frontiers in the pharmaceutical industry is the design of small molecules to perturb protein-protein interactions PPIs. Many medicinally validated protein targets involve PPIs, but the methods available to discover small molecules that perturb these are, on aggregate, inadequate. Small Molecule PPI Mimics LLC owns intellectual property cove ...

    STTR Phase I 2014 Department of Health and Human Services
  8. A novel 3D cell culture human uterine contractility assay for high-throughput scr

    SBC: n3D            Topic: NICHD

    DESCRIPTION (provided by applicant): Several disorders in reproductive medicine are results of changes in smooth muscle contractile activity. Increased myometrial contraction can lead to preterm labor, which affects 12% of the US population. However, the mechanisms involved in the transition from uterine quiescence to contractility at the onset of labor are not well-known. As a result, the managem ...

    STTR Phase I 2014 Department of Health and Human Services
  9. Protein Bound RNA Sequencing

    SBC: BIOO SCIENTIFIC CORPORATION            Topic: NHGRI

    DESCRIPTION (provided by applicant): Protein-RNA interactions make a profound contribution to the regulatory logic of post- transcriptional control of gene expression. Tools to decipher this intricate layer of molecular interactions on a global scale are coming to the forefront of molecular biology and genomics. The most wide spread methodology to examine interactions of RNA binding proteins (RBPs ...

    STTR Phase I 2014 Department of Health and Human Services
  10. Multi-functional particles for stem cell isolation and expansion

    SBC: Progenitec Inc.            Topic: NIMH

    DESCRIPTION (provided by applicant): The objective of this STTR Phase I proposal is to develop novel multi-layer microparticles and demonstrate their feasibility to isolate and expand stem cells for medical research and therapeutic applications. In recentyears, stem cells have been used in a wide variety of applications, including cell- based therapies, drug screening, and models to understand the ...

    STTR Phase I 2014 Department of Health and Human Services

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