Award Data

DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

DESCRIPTION (provided by applicant): Hiltonol (poly-ICLC) is a stabilized dsRNA therapeutic viral mimic or 'danger signal' that activates multiple elements of innate and adaptive immunity. It is a standalone immunomodulator, but when properly combined with antigen it generates a comprehensive Th-1 weighted immune response best suited for antiviral and antitumor action. This project will ...

The overarching objective of this project is to develop an innovative technological tool that will facilitate the implementation of an evidence-based substance abuse prevention program and related health behavior risk programs among military personnel. PUBLIC HEALTH RELEVANCE

Examining the effects of Motion and Voice Video Game on Relapse prevention in drug addicted youth. PUBLIC HEALTH RELEVANCE

DESCRIPTION (provided by applicant): There is no more important target audience for smoking cessation efforts than pregnant women. The goal of this Fast Track project is to establish the scientific and technical feasibility of using an interactive text- and web-based application to support smoking cessation among pregnant women. This project aims to develop the first-ever text message based smokin ...

DESCRIPTION provided by applicant This study will aim to assess the feasibility and acceptability of using state of the art video game technology to increase adherence among HIV adolescents and young adults AYA ages Treatment fatigue and the desire for increasing independence among this particular population can lead to non adherence which can result in treatment resistant HIV a cri ...

Optimization of generator performance and maximization of output power are difficult to attain in the generation of hydro-power. This is due to the changing water conditions and corresponding changes in the form of available energy. ESL proposes to use self-tuning controls in combination with a suitably chosen and optimized generator driven by hydro-energy and condition it for distribution to then ...

DESCRIPTION (provided by applicant): Pregnant women, particularly those from underserved populations, often have a multitude of behavioral risks that threaten positive pregnancy and birth outcomes, as well as the future health of mother and baby. This application represents innovative research for impacting the promotion of healthy behaviors among pregnant women. The objective is to develop and te ...

DESCRIPTION (provided by applicant): The overall goal of this application is to develop a quantitative in-vivo small animal imaging system for fluorescent reporter probes that fuses fluorescence light emitting computed tomography (FLECT) with X- ray computed tomography (CT). The proposed dual-modality imaging system will not only provide a research tool for better understanding of biological funct ...