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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Inter-alpha-inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. IGF::OT::IGF High-Impact Substance Abuse Prevention Technologies. SBIR Phase I. Period of Performance 7/16/2014-1/15/2015

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    The overarching objective of this project is to develop an innovative technological tool that will facilitate the implementation of an evidence-based substance abuse prevention program and related health behavior risk programs among military personnel. PUBLIC HEALTH RELEVANCE

    SBIR Phase I 2014 Department of Health and Human Services
  4. Promoting Health During Pregnancy: A Multiple Behavior Computer Tailored Interven

    SBC: Pro-Change Behavior Systems Inc            Topic: NCCDPHP

    DESCRIPTION (provided by applicant): Pregnant women, particularly those from underserved populations, often have a multitude of behavioral risks that threaten positive pregnancy and birth outcomes, as well as the future health of mother and baby. This application represents innovative research for impacting the promotion of healthy behaviors among pregnant women. The objective is to develop and te ...

    SBIR Phase II 2010 Department of Health and Human Services
  5. Immunotherapeutic Biomaterials for Treatment of Glioma

    SBC: IN CYTU, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): A Phase I SBIR program of preclinical development is proposed focusing on the development of an active specific immunotherapeutic called Cellarium for treatment of glial cell-based cancers. Successful completion of this project will establish the minimum level of therapeutic feasibility and lead to further development of the vaccine in preparation for f ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Role of Inter-alpha Inhibitors in Anthrax Intoxication

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Anthrax is recognized as a class A bio-threat microbial pathogen that is readily weaponized and exceedingly difficult to treat. This bacterium is highly virulent inducing lethal infection in immunologically normal hosts by its intrinsic capacity to disseminate rapidly and induce sepsis, along with its ability to generate two highly potent exotoxins, lethal toxi ...

    STTR Phase II 2010 Department of Health and Human Services
  7. Innovative Approaches to Low Power, Sub-Threshold Electronic Circuits

    SBC: CAMGIAN MICROSYSTEMS CORP            Topic: SB082045

    This program proposes to demonstrate an ultra-low power design methodology and circuits for digital logic employing advanced dynamic voltage scaling (DVS) for asynchronous NULL Convention Logic (NCL) circuits operating in sub-threshold to super-threshold voltage regimes. The power supply voltages of logic block partitions will be independently set by on-chip voltage controllers based on the data p ...

    SBIR Phase II 2010 Department of DefenseDefense Advanced Research Projects Agency
  8. Open System Manufacturing of Large Sensing/Weapons Platforms

    SBC: Applied Radar, Inc.            Topic: SB102005

    In order to maintain our nation’s technological superiority on air, sea and land, we must respond quicker to emerging threats and reduce the cost of major sensing platforms. Every DoD platform developed nowadays contains at least one sensor, whether it be RF, EO/IR, or acoustic. In fact, in a lot of recent developments, the platform is built around the sensor and exists only to support the senso ...

    SBIR Phase I 2010 Department of DefenseDefense Advanced Research Projects Agency
  9. Memory-based Graphics: A New Technology For Visual Interfaces And Interactive Visualization

    SBC: Infinite Graphics, Corp            Topic: N/A

    This project is based on a novel computer graphics technology for man/machine interfaces that relies on machine learning techniques, neural-like networks, and object recognition IU techniques. The key idea is to use a few "example" views of an object or person, to teach the computer to generate other views, under user control. WIth our technology we will develop an interactive (multimedia) interfa ...

    SBIR Phase I 1993 Department of DefenseDefense Advanced Research Projects Agency
  10. SOFTWARE REVERSE ENGINEERING TOOLS FOR INCLUSION IN OPEN ARCHITECTURE ENVIRONMENTS

    SBC: PROMETHEUS INC            Topic: N/A

    REVERSE ENGINEERING DERIVES THE SPECIFICATION OFA SOFTWARE SYSTEM FROM ITS IMPLEMENTATION. IT REQUIRES BOTH A SPECIFICATION LANGUAGE AND A SET OF TOOLS. AS OUR SPECIFICATION LANGUAGE WEUSE SEDL; AS OUR INPUT LANGUAGE WE USE C; AND AS OUR PROTOTYPE WORKING ENVIRONMENT WE USE ARCADIA. SEDL, A SOFTWARE ENGINEERING DESIGN LANGUAGE DEVELOPED AT IBM, IS AN EXTENSION TO ADA THAT PROVIDES HIGH-LEVEL DICTI ...

    SBIR Phase II 1993 Department of DefenseDefense Advanced Research Projects Agency

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