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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Inter-alpha-inhibitors in Hypoxic-Ischemic Brain Injury


    DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. In-Situ Autovaccination against Solid Cancers with Intratumoral Hiltonol (Poly-IC

    SBC: Oncovir            Topic: NCI

    DESCRIPTION (provided by applicant): Hiltonol (poly-ICLC) is a stabilized dsRNA therapeutic viral mimic or 'danger signal' that activates multiple elements of innate and adaptive immunity. It is a standalone immunomodulator, but when properly combined with antigen it generates a comprehensive Th-1 weighted immune response best suited for antiviral and antitumor action. This project will ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. IGF::OT::IGF High-Impact Substance Abuse Prevention Technologies. SBIR Phase I. Period of Performance 7/16/2014-1/15/2015

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    The overarching objective of this project is to develop an innovative technological tool that will facilitate the implementation of an evidence-based substance abuse prevention program and related health behavior risk programs among military personnel. PUBLIC HEALTH RELEVANCE

    SBIR Phase I 2014 Department of Health and Human Services
  5. IGF::OT::IGF RELAPSE PREVENTION MOTION AND VOICE VIDEO GAME; POP: 9/2/2014-9/1/2016; N44DA-14-4419 SBIR Phase II (Topic 150) Modification to Remove IT Risk Assessment requirements.

    SBC: MEDIA REZ LLC            Topic: NIDA

    Examining the effects of Motion and Voice Video Game on Relapse prevention in drug addicted youth. PUBLIC HEALTH RELEVANCE

    SBIR Phase II 2014 Department of Health and Human Services
  6. Developing and Scaling an interactive text messaging tool to help pregnantsmoker

    SBC: Voxiva, Inc            Topic: NIDA

    DESCRIPTION (provided by applicant): There is no more important target audience for smoking cessation efforts than pregnant women. The goal of this Fast Track project is to establish the scientific and technical feasibility of using an interactive text- and web-based application to support smoking cessation among pregnant women. This project aims to develop the first-ever text message based smokin ...

    SBIR Phase II 2014 Department of Health and Human Services
  7. Interactive Technology for Pediatric HIV/AIDS Treatment Adherence

    SBC: MEDIA REZ LLC            Topic: 105

    DESCRIPTION provided by applicant This study will aim to assess the feasibility and acceptability of using state of the art video game technology to increase adherence among HIV adolescents and young adults AYA ages Treatment fatigue and the desire for increasing independence among this particular population can lead to non adherence which can result in treatment resistant HIV a cri ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Integration of Complex Geometry, 3D Woven Preforms via Innovative Stitching Technique

    SBC: T.E.A.M., INC.            Topic: H701

    Thick, 3D woven carbon/phenolic composites offer potential improvement over legacy thermal protection systems (TPS) for re-entry vehicle heat shield applications. However due to the scale and complexity of typical re-entry vehicle structures, it is likely that multiple 3D woven panels would need to laid up to create the overall heat shield, creating a potential weak spots at the panel joints. ...

    SBIR Phase I 2014 National Aeronautics and Space Administration
  9. Advancing High Energy Lithium-Sulfur Batteries

    SBC: Yardney Technical Products, Inc.            Topic: Z102

    Lithium-Ion batteries have been a main source of energy for many aerospace applications over the past decade. Future space missions are facing a number of challenging requirements, including significant increase in specific energy, approaching 500 Wh/kg, and energy density of 700 Wh/l at cell level. Compared to state-of-the-art technology today, a reduction in mass and volume are necessary, along ...

    SBIR Phase I 2014 National Aeronautics and Space Administration
  10. Sensitive and Shape-Specific Molecular Identification

    SBC: RYON TECHNOLOGIES, INC            Topic: A11aT017

    The ability to rapidly detect, identify and monitor chemical agents remains a challenge of significant importance to the Armed Forces. Existing chemical sensing techniques have shortcomings that inhibit widespread implementation. To address this situation, Ryon Technologies is developing a portable instrument that is based on Rydberg Fingerprint Spectroscopy (RFS) in combination with mass spectrom ...

    STTR Phase II 2014 Department of DefenseArmy

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