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SK realistic estimated timeline of 18 months maximum, hopefully sooner, will allow for design, engineer and testing modifications to be addressed. SK learned from Phase II that even the simple modifications can result in hours of engineering and design work. The successful completion of the DOTWASH system was designed and developed. The overall components were tested with good operating capabiliti ...

Producers of solid and liquid biofuels need to reduce both capital and operating costs to achieve unsubsidized cost parity with fossil fuels. Many biomass feedstocks destined for conversion platforms must be dried, however, the capital cost for dryers is high due to long residence times and the operating cost is high due to system inefficiencies. Consistent and reliable operation of biomass dryers ...

Combustion of biomass, especially in small-scale applications, produces high emissions of particulate matter (PM) that have been linked to adverse health effects and global climate change. Current industrial particulate control solutions are prohibitively expensive for use in small scale biomass burners. To overcome these challenges, inexpensive and effective combustion control solutions for small ...

Female rainbow trout show improved uniformity of growth, more desirable carcass traits and reduced expression of sexual maturation compared to mixed-sex stocks, thus improving efficiency and return for the trout farming industry. As a result, all-female stocks are much more desirable, and currently comprise the vast majority (over 90%) of the rainbow trout sold in the US. Current methods of produc ...

The project team is developing a prototype of Eco, a multi-player game to prepare high school students to be environmentally literate citizens with 21st century skills. To play the game, students will enter a shared online world featuring a simulated ecosystem of plants and animals. Students will co-create the civilization by measuring, modeling, and analyzing the underlying ecosystem. Students ad ...

DESCRIPTION (provided by applicant): Female sexual arousal disorder (FSAD), one of the conditions commonly described as Female sexual dysfunction (FSD) is common among older women and can be a significant reason for decreased quality of life in the aging population. FSAD is defined as the persistent or recurring inability to attain or maintain sufficient sexual excitement, causing personal distres ...

DESCRIPTION (provided by applicant): The goal of this project is to extend the development of a novel compound that can reprogram memory T lymphocytes to induce tolerance in allergic rhinitis (AR). AR is one of the most common chronic diseases in the United States (US) and is estimated to affect more than 50 million people [1,2]. As a result, the annual US economic burden of AR exceeds 12 billio ...

DESCRIPTION (provided by applicant): The purpose of this proposal is to adapt a technology that we have developed for monitoring residual disease in leukemia patients to monitor residual autoimmune disease in Celiac Disease patients. Celiac disease hasa significant burden on quality of life, as it is one of the most frequent autoimmune diseases, with an estimated prevalence of approximately 1% ...

Project Summary Tumors survive cancer therapy in part by blocking the entrance and permeation of drugs into the cancer. We have developed a therapeutic, JO-1 , that selectively opens up tumors, which dramatically enhances penetration. This results in markedly increased concentrations of cancer drugs in the tumor, which becomes a sink , thereby reducing drug levels in the rest of the body. JO-1 m ...

DESCRIPTION (provided by applicant): With the discovery of new biomarkers associated with tumor development, many of these tumor-associated antigens (TAA) are being utilized in immunotherapeutic modalities designed to induce anti-tumor directed cytotoxicimmune responses. It is increasingly clear that not any one of these TAA is sufficient, as a single entity to develop an immunotherapeutic treatm ...