List

DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

The overarching objective of this project is to develop an innovative technological tool that will facilitate the implementation of an evidence-based substance abuse prevention program and related health behavior risk programs among military personnel. PUBLIC HEALTH RELEVANCE

Thick, 3D woven carbon/phenolic composites offer potential improvement over legacy thermal protection systems (TPS) for re-entry vehicle heat shield applications. However due to the scale and complexity of typical re-entry vehicle structures, it is likely that multiple 3D woven panels would need to laid up to create the overall heat shield, creating a potential weak spots at the panel joints. ...

Lithium-Ion batteries have been a main source of energy for many aerospace applications over the past decade. Future space missions are facing a number of challenging requirements, including significant increase in specific energy, approaching 500 Wh/kg, and energy density of 700 Wh/l at cell level. Compared to state-of-the-art technology today, a reduction in mass and volume are necessary, along ...

Applied Radar proposes to develop a high-gain low cost, size, power and weight (low-CSWAP) tactical common data link (TCDL) antenna for the Firescout and Predator UAVs. The improved TCDL antenna will support 6 or more nodes of high-gain full-duplex communication at 21.42 MBPS in a star network configuration with 360 degree coverage out to 110 nm slant range. In Phase 1, we will design, fabricate a ...

The ability to rapidly detect, identify and monitor chemical agents remains a challenge of significant importance to the Armed Forces. Existing chemical sensing techniques have shortcomings that inhibit widespread implementation. To address this situation, Ryon Technologies is developing a portable instrument that is based on Rydberg Fingerprint Spectroscopy (RFS) in combination with mass spectrom ...

YTP will develop technology that provides a high performance, modular Li-ion battery with: redundant safety features, safer thin, metal case cell designs; fin/micro-channel thermal control system; and an evaporating fluid system that rapidly quenches failing cells to prevent thermal runaway and fratricide. The end goal of the proposal is making a lighter, longer lasting, less expensive, safer JSF ...

BTech proposes the design and development of a low-profile, broadband, shear-mode piezocrystal acoustic transducer for deep submergence applications. The Phase I effort considers evaluation of design variants of shear mode transducers with increased pressure operation/tolerance and tradeoffs associated with the same. Design feasibility is supported with calculations of expected performance and whe ...

A multi-band dual-aperture SATCOM antenna is proposed to support rotary-wing aircraft thru-rotor performance at X, Ku and Ka-bands including Ku-band TCDL as an option. Our proposed effort focuses on a low-cost design with reduced height and leverages existing aperture and radome technology from our prime contractor partner Lockheed-Martin. It also leverages existing digital modem technology develo ...