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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. "Cyclodextrin diets for enhancing fish health"

    SBC: DIAMOND V MILLS, INCORPORATED            Topic: 87

    Aquaculture is the fastest growing food-producing sector in the world and accounts forapproximately 50% of the seafood consumed throughout the world. However, the demand for farmraisedfish has pushed fish production densities to new limits and this has increased the incidenceand spread of disease. There have been very few drugs developed for treating and preventingdiseases in fish. We have discove ...

    SBIR Phase I 2014 Department of Agriculture
  2. Code optimization for two-dimensional distributed soil loss modeling

    SBC: AGREN INC            Topic: 84

    Central Iowa-based small business, Agren, in collaboration with the ARS Sedimentation Laboratory and the University of Tennessee, has developed two GIS-based soil loss modeling tools. Each tool combines remotely-sensed, high-resolution digital elevation models (LiDAR) and newly developed hydrologic algorithms with long standing soil-loss modeling principles. The results to date are two-dimensional ...

    SBIR Phase I 2014 Department of Agriculture
  3. Next Generation Vaccine for Infectious Bovine Keratoconjuctivitis

    SBC: HARRISVACCINES, INC.            Topic: 83

    Currently available vaccines for infectious bovine keratoconjunctivitis (IBK), also known as "pinkeye", have poor efficacy and low cross-protection between strains. This may be partly due to the lack of mucosal antibody responses, which are not induced by traditional inactivated bacterin vaccines. The use of alphavirus replicon particle (RP) vaccines has been shown to induce muscosal imm ...

    SBIR Phase I 2014 Department of Agriculture
  4. The Iowa Assessment of Skills and Knowledge for Automatic Word Recognition and Decoding (iASK)

    SBC: Foundations In Learning, Inc            Topic: N/A

    The project team is developing a prototype of an online word recognition assessment program for middle school students who are struggling readers. The assessment will address a variety of literacy skills including decoding, fluency, and word recognition. The product will generate formative assessment profiles of individual students for teachers to provide targeted instruction. In the Phase I pilot ...

    SBIR Phase I 2014 Department of Education
  5. Gamma-ketoaldehyde scavengers for alcoholic liver disease

    SBC: MTI Biotech Incorporated            Topic: NIAAA

    DESCRIPTION (provided by applicant): Chronic alcohol overconsumption is the third largest risk factor for disease burden worldwide and is a frequent comorbidity of liver disease and cancer. While abstinence is a cornerstone of treatment, there is considerable interest in identifying other therapeutic interventions for alcoholic liver disease (ALD). Such advances are complicated by an incomplete un ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Quantitative Test of the Success/Reduction of Harm of Smoking Cessation Treatment

    SBC: BEHAVIORAL DIAGNOSTICS, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): Cigarette smoking is the most common preventable cause of morbidity and mortality in the United States. Over the past 20 years, several effective treatments, including varenicline, bupropion and nicotine replacement treatments (NRT, such as nicotine gum or patches) have been developed. Despite significant efforts, the overall success of these treatments for sm ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Development of a Porcine Model of Autosomal Dominant Polycystic Kidney Disease

    SBC: EXEMPLAR GENETICS, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common, potentially fatal genetic disorders in humans with an incidence of 1 in every 500-1000 individuals. The majority of ADPKD cases (85%) are caused by mutations in the PKD1 gene, which encodes polycystin-1. ADPKD is a systemic disorder that often leads to kidney failure and extrarenal ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Inter-alpha-inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. IGF::OT::IGF High-Impact Substance Abuse Prevention Technologies. SBIR Phase I. Period of Performance 7/16/2014-1/15/2015

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    The overarching objective of this project is to develop an innovative technological tool that will facilitate the implementation of an evidence-based substance abuse prevention program and related health behavior risk programs among military personnel. PUBLIC HEALTH RELEVANCE

    SBIR Phase I 2014 Department of Health and Human Services

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