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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Risk Reduction Toolkit for Non Prescription Syringe Sales in Community Pharmacies

    SBC: Hdox Bioinformatics Inc.            Topic: ODCDC

    A web based pharmacist training programand a patient centric decision support systemDSSfor pharmacies to implement risk reduction services for persons who inject drugsPWIDThe software will be interoperable with pharmacy and EHR systemsand generate tailored harm reduction counseling for PWIDA patient centric approach to decision support has the potential of improving the level of detail and accurac ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Topic 377: Symptom Management and Intervention Roadmaps (STaIRS)

    SBC: Carevive Systems, Inc.            Topic: NCI

    Numerous adverse symptoms are under-detected in cancer care resulting1-3 in missed opportunities for intervention; leading to poor treatment adherence, avoidable hospitalizations, and worse morbidity and survival. The IOM proposed shaking up the current symptom paradigm from reactive to proactive, personalized, technology-enabled models of symptom care as a solution to this clinical quality crisis ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. An integrated mobile and web-based application for problem cannabis use

    SBC: Checkup and Choices LLC            Topic: NIDA

    The objective of this research project is to develop an integrated set of digital tools that will deliver a brief motivational interventionBMIfor young adult marijuana users across a variety of platformsWe havein four randomized clinical trialsdemonstrated the effectiveness of similar tech based interventions for problem drinkingThese interventions have been integrated into one comprehensive progr ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. TFEB Activator for Alzheimer's Disease Therapy

    SBC: BRILLIANT BIOSCIENCES INC.            Topic: NIA

    One in ten of the persons ageare affected by Alzheimer s diseaseADcausing enormous social and economic burden to the United StatesTo date only five medications have been approved by the FDA for the treatment of the symptoms of ADbut none of them slows or stops the disease progressionWith the recent repeated failures of AD drugs on thesecretase inhibitorsthe need for an effective AD drug became eve ...

    STTR Phase I 2018 Department of Health and Human Services
  5. A high throughput next generation sequencing (NGS) pipeline to generate high quality recombinant therapeutic antibodies

    SBC: Specifica Inc.            Topic: 100

    Abstract Therapeutic antibodies are used to treat many different diseasesincluding cancerauto immunityinfection and atherosclerosisThey are the fastest growing class of pharmaceuticalswith annual revenues of$B inOne of the most important methods to select therapeutic antibodies is by selection from vast antibody librariesHowevergood libraries are extremely challenging to produceand commercially av ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Cpf1-mediated inactivation of an AAV transgene

    SBC: EMMUNE, INC.            Topic: NIAID

    PROJECT SUMMARY The Farzan laboratory has developed what appears to be an effective way to prevent HIVinfectionThis approach combines eCDIgan exceptionally broad and potent HIVentry inhibitorwith an adenoassociated virusAAVdelivery systemFor more than a year after a one time intramuscular inoculation with AAV eCDIgrhesus macaques were protected against multiple high dose intravenous challenges wit ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Development of a syringe/sonication device employed to administer DDFPe in the prehospital setting

    SBC: NUVOX PHARMA, L.L.C.            Topic: 101

    PROJECT SUMMARY ABSTRACT Clinical ChallengeIn acute traumain the civilian settinghemorrhage is the second most leading cause of deathIn the military settingof potentially preventable deaths are caused by hemorrhage due to traumaof civilian andof military mortality caused by traumatic hemorrhage occurs pre hospitalizationAdverse outcome in trauma patients during prehospital resuscitation is due to ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Novel Targeting of the S1P Receptor, S1P1, and Nox4 as Therapeutic Approaches in ARDS

    SBC: RESTORE THERAPEUTICS LLC            Topic: NHLBI

    PROJECT SUMMARYAcute Respiratory Distress SyndromeARDSis a devastating syndrome that afflicts more thanpatients in United States alone and has an unacceptably high mortality rate ofCurrently there are no therapies that address the loss of lung vascular barrier integrityvascular leakage and alveolar flooding that are critical features of ARDS pathobiologyThe PI was the first to demonstrate that sph ...

    STTR Phase I 2018 Department of Health and Human Services
  9. Preclinical studies of Selective and Orally Bioavailable Aurora B Inhibitors for the Treatment of AML

    SBC: SYNACTIX PHARMACEUTICALS, INC.            Topic: 102

    ABSTRACTThe Aurora Kinase FamilyAKFcomprises heavily pursued therapeutic targets for cancer because of their intimate involvement in cell division and tumor progressionNumerous therapeutic campaigns have been initiated against the AKFwith promising clinical successes emanating from strategies targeting either Aurora A or Aurora BHoweverthe US Food and Drug Administration has yet to approve a cance ...

    STTR Phase I 2018 Department of Health and Human Services
  10. Clinical mass spectrometry test for apolipoprotein C-III proteoforms

    SBC: Isoformix Inc.            Topic: 400

    PROJECT SUMMARY Only about dozen mass spectrometryMSprotein tests have been translated into clinical laboratories since the MALDI and ESI approaches were developed thirty years agoWhile the cost and complexity of these tests are important factors impeding their clinical adoptionnew content generated via proteoforms detection could provide the impetus for further development and translationOur rece ...

    SBIR Phase I 2018 Department of Health and Human Services

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