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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Universal Liquid Chromatography Detector Utilizing Reactive Flame Ionization Detection

    SBC: Activated Research Company, LLC            Topic: 400

    Abstract The analysis of moleculesanalytesby liquid chromatographyLCis performed in all areas of healthcare from drug discovery and development to disease diagnosisHerewe propose a near universal LC detector utilizing a flame ionization detectorFIDthat responds with high sensitivity to all organic compoundsThis technology has the potential to speed up pharmaceutical development and allow for more ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A Wearable Monitoring Device Used for the Assessment of Patients with Chronic Respiratory Diseases

    SBC: KORONIS BIOMEDICAL TECHNOLOGIES CORP.            Topic: NIA

    Abstract Koronis Biomedical TechnologiesKBTand its collaborates propose to develop a wearable system to monitor patient coughs at homeThe frequency and intensity of a patient s cough can be instrumental in the continual monitoring and treatment of many chronic respiratory conditionsCurrent clinical methods are limited and lack the ability to capture long term trends in the cough frequency and seve ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Development of a syringe/sonication device employed to administer DDFPe in the prehospital setting

    SBC: NUVOX PHARMA, L.L.C.            Topic: 101

    PROJECT SUMMARY ABSTRACT Clinical ChallengeIn acute traumain the civilian settinghemorrhage is the second most leading cause of deathIn the military settingof potentially preventable deaths are caused by hemorrhage due to traumaof civilian andof military mortality caused by traumatic hemorrhage occurs pre hospitalizationAdverse outcome in trauma patients during prehospital resuscitation is due to ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Novel Targeting of the S1P Receptor, S1P1, and Nox4 as Therapeutic Approaches in ARDS

    SBC: RESTORE THERAPEUTICS LLC            Topic: NHLBI

    PROJECT SUMMARYAcute Respiratory Distress SyndromeARDSis a devastating syndrome that afflicts more thanpatients in United States alone and has an unacceptably high mortality rate ofCurrently there are no therapies that address the loss of lung vascular barrier integrityvascular leakage and alveolar flooding that are critical features of ARDS pathobiologyThe PI was the first to demonstrate that sph ...

    STTR Phase I 2018 Department of Health and Human Services
  5. Preclinical studies of Selective and Orally Bioavailable Aurora B Inhibitors for the Treatment of AML

    SBC: SYNACTIX PHARMACEUTICALS, INC.            Topic: 102

    ABSTRACTThe Aurora Kinase FamilyAKFcomprises heavily pursued therapeutic targets for cancer because of their intimate involvement in cell division and tumor progressionNumerous therapeutic campaigns have been initiated against the AKFwith promising clinical successes emanating from strategies targeting either Aurora A or Aurora BHoweverthe US Food and Drug Administration has yet to approve a cance ...

    STTR Phase I 2018 Department of Health and Human Services
  6. Point of Care Neonatal Monitor using Non-Contact Sensors

    SBC: KORONIS BIOMEDICAL TECHNOLOGIES CORP.            Topic: NICHD

    Abstract Koronis Biomedical Technologies CorporationKBTproposes to develop a non contactbiologically safe radar system capable of monitoring the respiration rate and heart rate of neonatesPremature infants are a particularly vulnerable population within pediatrics that demonstrate an impending clinical change through subtle alterations in vital signs and therefore for whom constant monitoring is p ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Improved Non-Invasive Ventilation Triggering and Synchronization System Targeting Infants and Neonates

    SBC: Minnesota HealthSolutions Corporation            Topic: NICHD

    Project Summary AbstractMinnesota HealthSolutions Corporation and Children s Hospital Los Angeles propose the development and validation of a novel methodology for effective triggering and synchronization of non invasive ventilationNIVfor infants and children in the intensive care unitICUTechnology advancements in NIV have improved outcomes for critically ill patientsbut unfortunatelymost neonates ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Clinical mass spectrometry test for apolipoprotein C-III proteoforms

    SBC: Isoformix Inc.            Topic: 400

    PROJECT SUMMARY Only about dozen mass spectrometryMSprotein tests have been translated into clinical laboratories since the MALDI and ESI approaches were developed thirty years agoWhile the cost and complexity of these tests are important factors impeding their clinical adoptionnew content generated via proteoforms detection could provide the impetus for further development and translationOur rece ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Continuous emulsion digital PCR (cdPCR) for low-cost, rapid, near point-of-care genotyping of non-small cell lung cancer

    SBC: DropWorks, Inc.            Topic: 102

    PROJECT SUMMARY Genotyping of cancer has become the standard of carewhere specific mutations in cancer driving genes have been shown to indicate sensitivity or resistance to targeted treatmentsSampling of cell free DNAcfDNAin blood plasma could provide a non invasive means of performing this genotypingbut current methods are too complexslowdaysand expensivehundreds of dollarsto make use of this in ...

    STTR Phase I 2018 Department of Health and Human Services
  10. A badge-like exposure device for occupational safety and epidemiological study

    SBC: TF HEALTH CORPORATION            Topic: 113

    Abstract Chemical exposure poses a threat to the safety and health of each of usespecially those who work in certain industriessuch as petroleum extraction and refinery facilitiesmining industryand fertilizer factoriesVarious sensing technologies have been developed over the past decades to address the needbut a low cost and accurate personal exposure device that can track multiple chemical pollut ...

    SBIR Phase I 2018 Department of Health and Human Services
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