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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biodegradable Lubricants from Renewable Feedstocks

    SBC: Tetramer Technologies,L.L.C.            Topic: 88

    Current agriculture and off-road equipment requires the use of lubricants to ensure efficient operation of integral hydraulic and gear driven systems. The lubricants, either oils or greases, aid in reducing friction, dissipating heat, prevent oxidation, and seal of water and debris from vital areas of the equipment. During operation, equipment may have slight leaks or suffer catastrophic failures ...

    SBIR Phase I 2018 Department of Agriculture
  2. Culturally Aware Entrepreneurial Education

    SBC: Independent Platform, LLC            Topic: 86

    This proposal is a response to the Rural and Community Development needs outlined in the RFP to focus on efforts needed to enhance human capital development, build earnings capacity, increase labor force participation and/or promote job creation to the most vulnerable populations in rural communities. The Navajo community drastically underperforms the nation in creation of businesses and jobs for ...

    SBIR Phase I 2018 Department of Agriculture
  3. Proximity-Based Fire Alert Notifications for Hearing Impaired

    SBC: KnewTek            Topic: na

    This project develops smoke detector hardware and an associated smartphone application which, upon detection of an environmental threat (e.g., a fire), automatically pushes alert notifications directly to individuals who are Deaf or hard of hearing via a cellular telephone or smart device application. The alert notifications are transmitted to telephones or smart devices within proximity of the sm ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Nucleobase aminosugars with reduced ototoxicity

    SBC: NUBAD, LLC            Topic: Y

    PROJECT SUMMARYAminoglycosides are one of the cheapest and well known antibiotics in clinical use for overyearsbut one of the major limitations in their use is their ototoxicityWe are developing fast and low cost methods to develop aminoglycosides with antiribosomal activities and reduced toxicityIn this projectwe will identify novel aminoglycoside antibacterialsthat show reduced ototoxicityComple ...

    STTR Phase I 2018 Department of Health and Human Services
  5. Development of a syringe/sonication device employed to administer DDFPe in the prehospital setting

    SBC: NUVOX PHARMA, L.L.C.            Topic: 101

    PROJECT SUMMARY ABSTRACT Clinical ChallengeIn acute traumain the civilian settinghemorrhage is the second most leading cause of deathIn the military settingof potentially preventable deaths are caused by hemorrhage due to traumaof civilian andof military mortality caused by traumatic hemorrhage occurs pre hospitalizationAdverse outcome in trauma patients during prehospital resuscitation is due to ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Novel Targeting of the S1P Receptor, S1P1, and Nox4 as Therapeutic Approaches in ARDS

    SBC: RESTORE THERAPEUTICS LLC            Topic: NHLBI

    PROJECT SUMMARYAcute Respiratory Distress SyndromeARDSis a devastating syndrome that afflicts more thanpatients in United States alone and has an unacceptably high mortality rate ofCurrently there are no therapies that address the loss of lung vascular barrier integrityvascular leakage and alveolar flooding that are critical features of ARDS pathobiologyThe PI was the first to demonstrate that sph ...

    STTR Phase I 2018 Department of Health and Human Services
  7. Preclinical studies of Selective and Orally Bioavailable Aurora B Inhibitors for the Treatment of AML

    SBC: SYNACTIX PHARMACEUTICALS, INC.            Topic: 102

    ABSTRACTThe Aurora Kinase FamilyAKFcomprises heavily pursued therapeutic targets for cancer because of their intimate involvement in cell division and tumor progressionNumerous therapeutic campaigns have been initiated against the AKFwith promising clinical successes emanating from strategies targeting either Aurora A or Aurora BHoweverthe US Food and Drug Administration has yet to approve a cance ...

    STTR Phase I 2018 Department of Health and Human Services
  8. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human Services
  9. Clinical mass spectrometry test for apolipoprotein C-III proteoforms

    SBC: Isoformix Inc.            Topic: 400

    PROJECT SUMMARY Only about dozen mass spectrometryMSprotein tests have been translated into clinical laboratories since the MALDI and ESI approaches were developed thirty years agoWhile the cost and complexity of these tests are important factors impeding their clinical adoptionnew content generated via proteoforms detection could provide the impetus for further development and translationOur rece ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Continuous emulsion digital PCR (cdPCR) for low-cost, rapid, near point-of-care genotyping of non-small cell lung cancer

    SBC: DropWorks, Inc.            Topic: 102

    PROJECT SUMMARY Genotyping of cancer has become the standard of carewhere specific mutations in cancer driving genes have been shown to indicate sensitivity or resistance to targeted treatmentsSampling of cell free DNAcfDNAin blood plasma could provide a non invasive means of performing this genotypingbut current methods are too complexslowdaysand expensivehundreds of dollarsto make use of this in ...

    STTR Phase I 2018 Department of Health and Human Services

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