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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Backbone Degradable Polymer-drug Conjugates for the Treatment of Ovarian Cancer

    SBC: TheraTarget, Inc.            Topic: NCI

    DESCRIPTION provided by applicant The purpose of this Phase II STTR project is to develop a polymeric system for the combination delivery of two antineoplastic agents gemcitabine and paclitaxel Based on the successful results of the STTR Phase I award this Phase II proposal details the rationale and research plan for the synthesis and evaluation of in vivo efficacy of two novel macromolecula ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Cost-effective MHz rate Optical Coherence Tomography for biomedical applications

    SBC: WASATCH PHOTONICS, INC.            Topic: NIBIB

    DESCRIPTION provided by applicant During this SBIR Phase I project we propose to build and test in phantoms a prototype of an innovative cost effective Optical Coherence Tomography OCT system with a X increase in acquisition rate compared to commercially available systems Further development may add an additional X increased acquisition rate for a total of X Current market demand for ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Affinity-based delivery of Sirolimus for prevention of AV graft failure

    SBC: AFFINITY THERAPEUTICS, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant There are greater than million patients that suffer end stage renal disease requiring hemodialysis Long term vascular access is vital for these patients to undergo hemodialysis and is obtained via surgical construction of an arteriovenous AV fistula or interposition of an AV graft Failure of vascular access results in staggering rate of morbidity and ev ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Miniature Stimulator for Temporary Therapies

    SBC: SPR THERAPEUTICS, INC.            Topic: NICHD

    DESCRIPTION provided by applicant The goal of this project is to collect the safety and effectiveness clinical data necessary to commercialize the SMARTPATCH R system for post stroke shoulder pain PSSP The prevalence of stroke is approximately million in the US with additional persons surviving a stroke each year Moderate to severe shoulder pain develops in a quarter to a third ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Beta Amyloid Deposits Imaged with 18F-AZD4694 and Postmortem Histology

    SBC: Navidea Biopharmaceuticals, Inc.            Topic: NIA

    DESCRIPTION provided by applicant Navidea Biopharmaceuticals is developing F AZD as a diagnostic imaging agent to be used with PET scans to directly visualize beta amyloid A deposits in the brains of living patients A deposits in the brains of patients with dementia are diagnostic for Alzheimerandapos s Disease Al Alzheimerandapos s Disease patients have abundant deposits of A in t ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. [18F]NAV4694 Imaging to Identify MCI Patients at Risk for Alzheimer's Dementia

    SBC: Navidea Biopharmaceuticals, Inc.            Topic: NIA

    DESCRIPTION provided by applicant Navidea Biopharmaceuticals is developing F NAV as a diagnostic imaging agent that can be used to visualize beta amyloid A plaques in the brains of living individuals Alzheimerandapos s disease is the leading cause of dementia All patients with dementia caused by Alzheimerandapos s disease have abundant A plaques in their brains There is a great need ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Helium Free MRI Image Guided Radiation Therapy (IGRT) System for ViewRay Inc

    SBC: HYPER TECH RESEARCH, INC.            Topic: 102

    DESCRIPTION provided by applicant This NIH Bridge Grant will result in a conduction cooled liquid helium free MRI background magnet for a commercial image guided radiation treatment IGRT for cancer treatment The program will ensure the successful continued commercialization of our customerandapos s image guided radiation therapy IGRT system a vital cancer treatment device now treating p ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Blocking a novel cytokine signaling pathway for the treatment of rheumatoid arthr

    SBC: NAVIGEN, INC.            Topic: NIAMS

    DESCRIPTION provided by applicant In spite of remarkable progress in management of rheumatoid arthritis RA a devastating autoimmune disease that affects million Americans causing chronic inflammation of joints and surrounding tissues the gap of unmet needs in this therapeutic field remains wide open First of all almost of the patients do not respond adequately to the most advanced ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. LIVERCHIP- A diagnostic tool for genetic liver diseases

    SBC: P2D, INC            Topic: 300

    DESCRIPTION provided by applicant Genetic mutations are known to cause acute and chronic liver diseases and are being increasingly recognized as drivers of phenotype severity As a group these diseases represent a substantial disease burden in the United States and constitute a diagnostic challenge in the clinical evaluation of affected patients In a Phase I Award we developed the JAUNDICE ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Treatments to Abolish Inflammatory Mediators in Hemodialysis

    SBC: Novelmed Therapeutics Inc            Topic: 400

    DESCRIPTION provided by applicant NovelMed intends to develop a humanized anti Bb antibody as a prophylactic treatment for inflammatory responses associated with hemodialysis During this procedure blood contacts the artificial surfaces of the dialyzer activating the alternative complement pathway AP AP activation causes cellular activation and production of inflammatory mediators with po ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health

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