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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Genetically Enhanced Nitrogen Fixation with Algae Biofilms

    SBC: Fulcrum Bioscience, LLC            Topic: 87

    This project will develop an algae-base nitrogen fixation process for commercial ammonia production for the agronomy market. This process operates under standard conditions. The technology utilizes a whole-cell mutant algae strain grown on an electrode surface and takes advantage of enzymatic pathways to make ammonia at standard conditions. The primary inputs are electricity and water. Compared to ...

    SBIR Phase I 2017 Department of Agriculture
  2. Testing feasibility and scalability of a new engineered design of an aerated static pile composting system.

    SBC: Compost Plant, L3C, The            Topic: 86

    Food waste is a significant and complex problem for the United States. Americans generate over 250 million (short) tons of trash a year, and organic materials such as paper and paperboard, yard trimmings, and food waste continue to make up a large component of the waste stream. These organic materials collectively account for a significant portion of U.S. methane emissions, as organic waste produc ...

    SBIR Phase I 2017 Department of Agriculture
  3. High throughput multiplexed characterization and modeling of antibody antigen binding with application to HSV

    SBC: Carterra, Inc.            Topic: NIAID

    Abstract All therapeutic antibodies and most vaccines critically depend on the ability of antibodies to specifically recognize particular antigens consequently detailed characterization of antibody antigen binding can provide invaluable information to understand and guide development Unfortunately due to the time and expense required atomic resolution structure determination is typically use ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a DNA Aptamer Based Electrochemical Assay for Acetazolamide in Urine Using a Handheld Biosensor for Compliance Validation in Clinical Drug Trials

    SBC: ApolloDx , LLC            Topic: NIDA

    Development of a DNA Aptamer Based Electrochemical Assay for Acetazolamide in Urine Using a Handheld Biosensor for Compliance Validation in Clinical Drug Trials Thirty to over eighty percent of patients enrolled in pharmaceutical clinical trials do not comply with trial protocols by discarding the drug under investigation or not using the proper dosages This common practice compromises the medica ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Tessa Sleep Quality Monitoring

    SBC: EPITEL, INC.            Topic: NHLBI

    ABSTRACT TessaTM is validated medical device wearable capable of providing clinical sleep quality metrics for multiple nights to assess the efficacy of a sleep disorder treatment Tessa records the forehead EEG to stage sleep in an automated report that tracks changes in sleep architecture before and after a treatment for many sleep disorders such as obstructive sleep apnea and insomnia There is ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Stream Dx: accurate and efficient, point-of-care uroflometry for improved diagnosis, monitoring, and post-treatment evaluation of LUTS

    SBC: STREAM DX, INC            Topic: 300

    PROJECT SUMMARYABSTRACT Lower urinary tract symptomsLUTSis one of the most common medical problems among older menaffectingof men by the time they reachyears of age andby the time they reach the age ofLUTS is a progressive disease that has been shown to significantly increase the risk of depression and reduce quality of lifeDue to thisearly detection and active management of LUTS is criticalUroflo ...

    SBIR Phase II 2017 Department of Health and Human Services
  7. Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, LLC            Topic: 105

    Neonatal hypoxia ischemiaHIremains a major cause of acute perinatal brain injuryleading ultimately to neurologic dysfunction manifesting as cerebral palsymental retardationand epilepsyUnfortunatelycurrent treatment and prevention strategies in newborns are limitedThere are no currently available therapies to prevent treat and or attenuate brain damage in premature infants other than supportive car ...

    SBIR Phase II 2017 Department of Health and Human Services
  8. ARF6 Inhibitors for Treatment of Acute Lung Injury

    SBC: NAVIGEN, INC.            Topic: NHLBI

    PROJECT SUMMARYAcute lung injuryALIand acute respiratory distress syndromeARDSresult from a common pathogenic processpulmonary injury or infection triggers an overwhelming inflammatory responsecytokine stormthat results in increased endothelial and epithelial permeability and efflux of inflammatory cellsproteinand water from the vascular system into the alveolar spaceThe further release of inflamm ...

    SBIR Phase II 2017 Department of Health and Human Services
  9. Recombinant Silk Elastin-like Protein Polymers for the Embolization of Cerebral Aneurysms

    SBC: TheraTarget, Inc.            Topic: 106

    NARRATIVE This STTR Phase I proposal details the rationale and the research plan for the development of a novel liquid embolizing agent composed of the genetically engineered protein polymerSELPsilk elastinlike proteinKto embolize cerebral aneurysmsThe SELP embolic would reduce the risk of aneurysm rupture while minimizing the risk of recanalization after treatment and providing a platform for del ...

    STTR Phase I 2017 Department of Health and Human Services
  10. Therapeutic D-peptide Inhibitor of HIV Entry

    SBC: NAVIGEN, INC.            Topic: R

    PROJECT SUMMARYWhile modern HIV combination therapy has transformed HIV into a manageable chronic infection for many patientsHIV AIDS remains a formidable global epidemicDespite the effectiveness of combining drugs from different classesside effects and drug resistance remain serious concerns for these life long therapiesThusthere is an enduring need for novel HIV inhibitors with new mechanisms of ...

    SBIR Phase II 2017 Department of Health and Human Services

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