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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Evaluation of a split-pond production system for baitfish culture

    SBC: HARRY SAUL MINNOW FARM, INC.            Topic: 87

    Arkansas produces 80 percent of all the baitfish in the US and annually exports more than 6 billion baitfish nationwide. However, baitfish farmers have suffered from a productivity reduction due to serious fish losses resulting from interminable predation and extensive inventory control in traditional ponds. Recently, unprecedented bird predation and unknown factors, possibly due to climate change ...

    SBIR Phase I 2014 Department of Agriculture
  2. A Self-Contained Assay Device for Rapid Detection of Viable Cryptosporidium in Wa

    SBC: Biodetection Instruments, Inc            Topic: NIAID

    DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will investigate the technical feasibility of an in vitro excystation-based automated cartridge assay for rapid detection of viable Cryptosporidium oocysts in water. Briefly, viable oocysts will be subjected to an in vitro excystation step to release sporozoites and the antigens for detection on a patent-p ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Targeted Enzyme Replacement Therapy for Rare Forms of Osteogenesis Imperfecta

    SBC: Biostratagies, LC            Topic: NIAMS

    DESCRIPTION (provided by applicant): The long-term goal of this project is to develop an effective protein replacement therapeutic (PRT) for patients affected with rare forms of Osteogenesis imperfecta, OI-VIII (deficiency in prolyl 3-hydroxylase 1; P3H1)and OI-VII (deficiency in cartilage associated protein CRTAP). These PRTs will integrate the safety and cost advantages of plant-based bioproduct ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Co-Construction for AAC Devices

    SBC: INVOTEK, INC.            Topic: NIDCD

    DESCRIPTION (provided by applicant): There are approximately 4 million Americans with severe speech and physical impairments (SSPIs) who must rely on augmentative and alternative communication (AAC) systems to express themselves. People with SSPI are at asignificant disadvantage when communicating. AAC systems place heavy cognitive and physical demands on users, resulting in very slow communicatio ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. A Panel-Based Approach to the Diagnosis of Genetic Nephropathies Utilizing Next G

    SBC: NEPHROPATHOLOGY ASSOCIATES, PLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): There are currently mutations in over 200 genes that have been described to cause kidney disease. Current strategies for diagnosis of genetic kidney disease are extremely costly and time consuming. We aim to develop a comprehensive next generation sequencing panel that can simultaneously test for all currently described kidney- associated gene mutations at a lo ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Quad-Rider Accessible Handcycle

    SBC: INVOTEK, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): Physical activity may improve the health and quality of life of people with spinal cord injury and disease (SCI/D) by slowing or reversing physiological decline, lowering risk factors for cardiovascular disease and diabetes, improving mental health status and independence, and promoting the efficient performance of daily activities. Unfortunately, lack of acc ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Comprehensive Telecommunication for People with Tetraplegia

    SBC: INVOTEK, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): There are over 700,000 Americans with severe physical impairments (SPIs) who have few options for independently accessing telecommunication services such as voice calls, text messaging, and video calling. The inabilityto independently and reliably access these services impacts many aspects of their lives. Nurturing friendships becomes more difficult, it is pra ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Enzyme Replacement Therapy for GM1 Gangliosidosis Lysosomal Rare Disease

    SBC: Biostratagies, LC            Topic: NINDS

    DESCRIPTION (provided by applicant): The goal of this proposal is to develop an effective enzyme replacement therapy (ERT) for patients suffering from GM1 Gangliosidosis by integrating a novel protein fusion ERT cell delivery strategy under development atBioStrategies LC and by exploiting safety, supply, and cost advantages of new plant-based enzyme therapeutics bio-manufacturing systems. GM1 Gan ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Inter-alpha-inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

    SBIR Phase I 2014 Department of Health and Human Services

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