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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Electrocatalytic Oxidation of Lignin to High-Value Aromatics

    SBC: Faraday Technology, Inc.            Topic: 81

    Significant quantities of biomass are produced annually which represent a huge possible feedstock for biofuels and other valuable chemicals and materials. Numerous industrial processes are available for utilization of the cellulosic fraction of this biomass. However, as much as 40-50% of the biomass is composed of lignin, a cross-linked, aromatic polymer, for which at present there are few economi ...

    SBIR Phase I 2014 Department of Agriculture
  2. Removal of pharmaceuticals and nutrients from agricultural drainage water using nano-engineered porous ceramic media

    SBC: METAMATERIA TECHNOLOGIES, LLC            Topic: 84

    Controlled agricultural drainage is used extensivelyin the U.S. for better crop production; howeverdisposalor re-use of these contaminant-laden agricultural water has been questioneddue toassociated impacts on water quality and food safety.Discharge of excess nutrients, such as nitrogen and phosphorus, into receiving water bodiesoftenresults in eutrophication (even hypoxia) in surface waters, as w ...

    SBIR Phase I 2014 Department of Agriculture
  3. Virus-like-particle (VLP) vaccines for infectious bursal disease virus (IBDV).

    SBC: LARAD Inc.            Topic: 83

    Developing nations rely on poultry as their major protein source. Maintaining poultry health is of critical importance to good human nutrition worldwide. Infectious bursal disease is a contagious immunosuppressive disease affecting nearly all poultry producing regions of the world. The disease is caused by infectious bursal disease virus (IBDV) a bi-segmented double-stranded RNA virus. Vaccination ...

    SBIR Phase I 2014 Department of Agriculture
  4. Development of novel malaria parastie metabolite-based non-invasive diagnostic biosensor

    SBC: GUILD ASSOCIATES, INC.            Topic: N/A

    The long term goal of the project is to use malaria parasite specific low-molecular-weight metabolites as biomarkers for development of sensitive, low-cost, simple, battery-operated field-deployable urine or saliva diagnostic biosensor for detection of malaria infection. Four malaria parasite-specific metabolites (3-Methylindole, Succinylacetone, S-Methyl-L-thiocitrulline, O-Arachidonoyl Glycidol ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. SBIR Phase II: Optimization of Rotavirus Vaccine Production

    SBC: Meridian Life Sciences, Inc.            Topic: N/A

    To improve the safety and efficacy of oral rotavirus vaccines, CDC scientists have developed a proprietary inactivated rotavirus vaccine (IRV) technology (new human strains and a novel method for rotavirus inactivation) and demonstrated the immunogenicity in mice [14] and protective efficacy in piglets [15] of this IRV by intramuscular (IM) administration. More recently, CDC scientists have demons ...

    SBIR Phase II 2014 Department of Health and Human Services
  6. Clear Cues: Supportive Wayfinding for Care Communities

    SBC: Linda-&-Cameron, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): The purpose of this project is to develop and test Clear Cues (CC), a signage system for care communities that supports way finding in people with dementia. Way finding is a process through which people use informationin the environment to help them get to their desired destination. It's both the user experience of choosing a path and the design elements t ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Novel Alzheimer's Disease Drug Treatment

    SBC: P2D, INC            Topic: NIA

    DESCRIPTION (provided by applicant): P2D Bioscience is developing the selective, non-addicting dopamine transport (DAT) inhibitor, PD2XXX, for the symptomatic treatment of Alzheimer's disease (AD). The core symptom of AD is short-term memory impairment. (DSM-IV) In preliminary studies, PD2XXX improved short term memory by over 110% in a well-accepted triple transgenic mouse model of AD (3xTg ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. A novel antisense therapeutic for treatment of Aspergillus fumigatus infections

    SBC: GUILD ASSOCIATES, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Guild proposes to develop an antisense oligomer-based antifungal effective against the human pathogen Aspergillus fumigatus. With a 40%-60% mortality rate, invasive aspergillosis (IA) due to A. fumigatus now surpasses invasive candidiasis as the most frequent fungal cause of death, especially amongst immunocompromised patients. Successful therapy for IA with cu ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Targeting the Core Binding Factor tumor suppressor in MLL-fusion AML

    SBC: P2D, INC            Topic: NCI

    DESCRIPTION (provided by applicant): RUNX1 is considered a beneficial tumor suppressor in myeloid neoplasms. Inhibition of RUNX1 function has been implicated as an important mechanistic event in the development of core-binding factor-(CBF)-leukemia and MLL-fusion leukemia. Inactivating RUNX1 mutations are frequently found in patients with acute myeloid leukemia (AML). However, RUNX1 mutation is us ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Fecal DNA Testing for Colorectal cancer Screening

    SBC: GLC Biotechnology, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): This is the Phase I application of a SBIR project that will be devoted to develop a new fecal DNA test for CRC screening, which will utilize a new tri-marker panel discovered in our preliminary study. CRC is the seconddeadliest cancer in USA. The good news is that early detection along with resection is associated with a five-year survival rate of nearly 100%. ...

    SBIR Phase I 2014 Department of Health and Human Services

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