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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Randomized Prospective Phase II Clinical Trial of NVX-108 in Association with Chemoradiation of Glioblastoma

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Glioblastoma multiforme (GBM) is a malignant primary brain tumor affecting about 12,000 new cases per year in the U.S. Average survival is only about 14-15 months. Radiation (RT) is most commonly administered as 30 fractions of 2 Gray each over 6-weeks with concomitant temozolomide (TMZ). GBM tumors are hypoxic. The primary mechanism of RT is creation of singlet oxygen; hypoxia within GBM adversel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. An Integrated Microarray Printing and Detection System

    SBC: BIOSENSING INSTRUMENT INC            Topic: 400

    DESCRIPTIONprovided by applicantMicroarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugsTypicallyprotein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another deviceDuring each testing cyclethe entire microarray becomes exposed to the pro ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. SBIR Phase I: Novel Plasma Actuator for Improved Wind Turbine Performance

    SBC: AQUANIS, INC.            Topic: MI

    The broader impact/commercial potential of this project is the reduction in the cost of renewable energy. The dramatic decline in the cost of wind energy over the last several decades has been fueled by the ever increasing turbine size and the introduction of new manufacturing methods and materials. However, the industry is approaching the limits of this trend due to the increased wear and tear of ...

    SBIR Phase I 2017 National Science Foundation
  4. SBIR Phase I: High multiplex visual mapping of heterogeneity in FFPE biospecimen

    SBC: BIOSYNTAGMA, LLC            Topic: BM

    This SBIR Phase I project will address drug resistance in cancer patients through the advanced analysis of biopsies. Not only is each patient unique but their tumor contains a high level of genetic diversity as well. Overlooked diversity within patient tumors can lead to inadequate treatment and consequently acquired drug resistance, and has also been shown to predict therapeutic response to certa ...

    SBIR Phase I 2017 National Science Foundation
  5. SBIR Phase I: Weft: Simulation Software for Textile Design and Manufacturing

    SBC: COMPUTATIONAL TEXTILES, INC.            Topic: IT

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to revolutionize the way that woven textiles are designed and manufactured. The textile industry is currently organized around fixed catalogs of fabrics, with significant barriers to the introduction of new products, including limited access to industrial equipment. The project will create ...

    SBIR Phase I 2017 National Science Foundation
  6. SBIR Phase II: Quasi-Active Prosthetic Ankle System: Dynamic Angle and Stiffness Optimizations for Multiple Gait Activities

    SBC: Springactive, Inc.            Topic: EW

    The broader impact/commercial potential of this project is that the proposed system will enhance the ability of the 1.3 million people currently living in the United States with a lower limb amputation to walk in unconstrained environments. The proposed Quasi-Active Prosthetic Ankle System (QPAS) addresses the RH6: Human Assistive Technologies area. QPAS will be lightweight, have a long battery li ...

    SBIR Phase II 2017 National Science Foundation
  7. Disaggregation of Toxic Protein Oligomers in Brain with Electromagnetic Treatment

    SBC: NeuroEM Therapeutics, Inc.            Topic: 104

    ABSTRACT Formation of misfolded protein oligomers in neurons is an early and causative event in a variety of neurodegenerative diseases such as Alzheimer s Disease amyloid and tau oligomers Fronto temporal lobe dementia tau oligomers and Parkinson s Disease synuclein oligomers These toxic oligomers share a common aggregation mechanism that involves formation of hydrogen bonds betwee ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Tools for Accelerating R&D for Historically Understudied Protein Kinases

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: NCATS

    Protein kinases are central players in almost every aspect of human physiology and serve as critical mediators of signal transductionThe dysfunction of many kinases is implicated in cancerdiabetesinflammationand cardiovascular diseases and many are validated targets for therapeutic interventionThe human genome encodesprotein kinasesYettheor so marketed protein kinase drugstarget only a small fract ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Solar-Powered High-Efficiency CO2 Refrigeration Technologies

    SBC: SUNDANZER DEVELOPMENT INCORPORATED            Topic: NonDoD

    SunDanzers High efficiency Refrigeration Unit (HERU) technology is a variable speed, two stage refrigeration platform, initially developed under Army SBIR topic A04-210, and continuing with Army Rapid Innovation Funding. HERU currently uses the military standard hydrofluorocarbon R-134a, vehicle type refrigerant. R-134a leaking into the atmosphere has 1400 times the greenhouse gas effect compared ...

    SBIR Phase II 2017 Department of DefenseArmy
  10. Dodecafluoropentane Prevents Ischemia Reperfusion Injury in Contemporary Acute Myocardial Infarction Management

    SBC: NUVOX PHARMA, L.L.C.            Topic: NHLBI

    Due to multiple factors time to administration of lytic therapy or emergent percutaneous coronary intervention PCI in acute ST segment elevation myocardial infarction STEMI may be delayed resulting in loss of additional myocardial tissue These delays are virtually impossible to overcome in remote regions and are associated with increased mor ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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