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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Rapid Detection of Endemic Fungal Infections in the U.S.

    SBC: NANOSHELL COMPANY, LLC            Topic: N/A

    Lectin recognition of fungal cell wall polysaccharides will be used to develop a rapid screening chip technology for the detection endemic fungal infection in blood. Fungal infections are life threatening to immune-compromised and immuno-suppressed patients (i.e. premature and malnourished infants, AIDS and cancer patients. seniors, and organ donation recipients). In addition to routine screenin ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. A Quantum Similarity Approach for the Discovery of Anti-Trypanosome Drug Leads

    SBC: GRADIENT BIOMODELING, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Human African trypanosomiasis (HAT) is an infectious disease with a large global health burden occurring primarily in Central and Eastern Africa. HAT is 100% fatal if untreated and the current drug therapies suffer frompoor safety profiles, difficult treatment regimens, limited effectiveness, and high costs. Furthermore, drugs that cross the blood brain barrier ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Multiplexed Ovarian Cancer Microfluidic Tissue Microarray

    SBC: Carterra, Inc.            Topic: NCI

    Project Summary We propose an instrument system for automated, multiplexed cell- and tissue-based experiments (i.e. tissue microarrays) called the Microfluidic Flow Cell Array (MFCA). The MFCA consists of a microfluidic flow cell array integrated with an inverted fluorescent microscope, allowing the observation of 48 flow chambers simultaneously or an individual chamber at higher magnification. Th ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. The Development of Novel Inhibitors of BCL2 Gene Expression as Anticancer Therape

    SBC: TETRAGENE, LLC            Topic: NCI

    Project Summary Evasion of apoptosis is a hallmark of cancer and is associated with oncogenesis, tumor maintenance, and resistance to conventional chemotherapy. BCL-2 was the first identified anti-apoptotic factor and is a member of the BCL-2 family of proteins that cooperate in the regulation of programmed cell death. BCL-2 plays a dominant role in the survival of multiple lymphoid malignancies a ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Immune-based brain cancer diagnostic for rapid, accurate disease classification

    SBC: HealthTell Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Accurate, early disease diagnosis and monitoring are critical aspects to effective prevention, treatment, and remission of disease. Most diagnostic methods available today are not simple or sensitive enough to significantly impact patients' response to treatment or survival outcome. This unmet need is highlighted by diseases, such as brain cancers, that o ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Targeting ether lipid biosynthesis for disease

    SBC: ECHELON BIOSCIENCES, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Cancer is a significant health burden in the US and across the globe, representing the second leading cause of death in the US. Cancer cells have metabolic pathways that are altered significantly compared to normal cells. As a result, the pathways involved (lipid biosynthesis for example) are considered excellent targets for therapeutic intervention. The levels ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Glycosaminoglycans to Treat and Prevent Radiation-Induced Oral Mucositis

    SBC: GLYCOMIRA, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): GlycoMira Therapeutics has developed safe and effective anti-inflammatory glycosaminoglycan derivatives and proposes to test the feasibility of using its lead compound to treat or prevent oral mucositis. Mucositis is acommon and debilitating complication of cancer treatment. Cancer patients undergoing radiation or chemotherapy often develop this painful inflam ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Enhancing longevity of implanted medical devices

    SBC: PIEZO ENERGY TECHNOLOGIES, L.L.C.            Topic: NIBIB

    DESCRIPTION provided by applicant Advanced methods for wirelessly recharging batteries for implanted medical devices are needed The useful lifetime of most implants is constrained by the longevity of the power source The goal of this program is to implement the development of an UltraSound Electrical Recharging system USerTM within a clinically deployed gastric sphincter stimulation system ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Detachable Nozzle Piezoelectric Dispense System for Cryo-TEM Sample Preparation

    SBC: ENGINEERING ARTS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Project Summary / Abstract Engineering Arts (EA) proposes the development of a detachable nozzle piezoelectric dispense system for use in Cryo-TEM (Cold - Transmission Electron Microscopy) sample preparation instrumentation. Cryo-TEM is an important tool for studying the structure of biological macromolecules in their native aqueous state. The challenging and l ...

    SBIR Phase I 2014 Department of Health and Human Services

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