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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Surface-covering gels for broad-spectrum antimicrobial protection following open

    SBC: SONORAN BIOSCIENCES, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): About 3-4% of all fractures are estimated to be open fractures, where the fracture is exposed through defects in the skin and soft tissues. This equates to about 250,000 open fractures in the United States annually. Open fractures present a high risk of infection. Infection results in considerable financial burden to both the patient an healthcare system, requ ...

    STTR Phase I 2014 Department of Health and Human Services
  2. Hepatitis C Virus RNA-Targeted Therapeutics

    SBC: VIOGEN BIOSCIENCES, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection is a significant human health issue, accounting for 50% of liver transplants in the US, with approximately 170 million persons infected worldwide. The current standard of care therapy of PEGylated-interferon and ribavirin is effective in only about 50% of patients, with severe side effects and contraindications limiting patient ...

    STTR Phase I 2014 Department of Health and Human Services
  3. Selective activation of the vagus nerve as an improved therapy for heart failure

    SBC: BLACKROCK MICROSYSTEMS            Topic: NHLBI

    DESCRIPTION (provided by applicant): The goal of the proposed project is to alleviate the enormous public health burden of heart failure. Heart failure leads to significant morbidity and mortality, affects almost five million Americans, and results in morethan 35 billion dollars in annual healthcare costs. Current pharmacological and surgical treatments are only moderately effective and can have s ...

    STTR Phase I 2014 Department of Health and Human Services
  4. Backbone Degradable Polymer-drug Conjugates for the Treatment of Ovarian Cancer

    SBC: TheraTarget, Inc.            Topic: NCI

    DESCRIPTION provided by applicant The purpose of this Phase II STTR project is to develop a polymeric system for the combination delivery of two antineoplastic agents gemcitabine and paclitaxel Based on the successful results of the STTR Phase I award this Phase II proposal details the rationale and research plan for the synthesis and evaluation of in vivo efficacy of two novel macromolecula ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Slip Flow Chromatography

    SBC: BIOVIDRIA, INC.            Topic: 100

    DESCRIPTION provided by applicant The goal of this STTR Phase II collaboration between Purdue University and bioVidria Inc is to commercialize disruptive new technology for protein chromatography and then maximize its impact by serving the fastest growing segment of the pharmaceutical industry protein drugs The product is a reversed phase chromatography column that uses silica particles of ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Commercialization of a Diagnostic test for amyotrophic lateral sclerosis (ALS)

    SBC: IRON HORSE DIAGNOSTICS, INC.            Topic: 101

    DESCRIPTION provided by applicant Amyotrophic lateral sclerosis ALS or Lou Gehrigandapos s disease is a fatal neurodegenerative disease with a typical lifespan of years after diagnosis The initial symptoms can be similar to many other neurologic disorders and often begin with limb weakness muscle fasciculations or increasing difficulties in speech or breathing No definitive diagnost ...

    STTR Phase II 2014 Department of Health and Human Services
  7. Ultrastable and Compact Deep UV Laser Source for Raman Spectroscopy

    SBC: TIPD, LLC            Topic: T801

    Deep-ultraviolet (UV) Raman spectroscopy is a powerful method to collect chemically specific information about complex samples because deep-UV (?? < 250 nm) excitation shows an over 200-fold greater efficiency compared to commonly used 785 nm excitation and has the ability to avoid fluorescence background in the Raman spectra. The availability of compact, robust, and reliable deep-UV laser source ...

    STTR Phase I 2014 National Aeronautics and Space Administration
  8. Ultra High Temperature Refractory Materials

    SBC: ADVANCED CERAMICS MANUFACTURING, LLC            Topic: T1001

    Legacy refractory materials that have origins dating to the original Saturn program are commonly used in current launch facilities. Although they fail to meet the target requirements, they are the only approved material. Our research team has demonstrated a baseline system during the Phase I effort that combines a non-cement binder, a high temperature macro aggregate, and reactive nano aggregates ...

    STTR Phase II 2014 National Aeronautics and Space Administration
  9. Sensitive and Shape-Specific Molecular Identification

    SBC: RYON TECHNOLOGIES, INC            Topic: A11aT017

    The ability to rapidly detect, identify and monitor chemical agents remains a challenge of significant importance to the Armed Forces. Existing chemical sensing techniques have shortcomings that inhibit widespread implementation. To address this situation, Ryon Technologies is developing a portable instrument that is based on Rydberg Fingerprint Spectroscopy (RFS) in combination with mass spectrom ...

    STTR Phase II 2014 Department of DefenseArmy
  10. Scale up of EO polymers and their utilization in novel nano-imprinted sub-wavelength waveguide-based Modulators and Arrays

    SBC: TIPD, LLC            Topic: AF11BT01

    ABSTRACT: The Phase II technical objectives follow directly from the Phase I effort, where all tasks necessary for RF photonic receiver fabrication were demonstrated. The Phase II effort will pursue two major objectives: 1) further development of SEO100 EO polymer based chips, packaged devices and arrays in collaboration with University of Dayton (antenna designs), taking advantage of multiphoto ...

    STTR Phase II 2014 Department of DefenseAir Force

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