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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A Low Cost Sensor for Mid-Chord Offset Measurements

    SBC: En'urga Inc.            Topic: 141FR1

    This Phase I SBIR project will evaluate the feasibility of utilizing low cost and high accuracy local position sensors and transmitters to autonomously estimate Mid-chord offset in rails. The two innovative parts of the proposed system are (1) a set of miniature and highly accurate local position sensors and transmitters for estimating the absolute positions of the mid point and end points of a 62 ...

    SBIR Phase I 2014 Department of Transportation
  2. Rapid Detection of Endemic Fungal Infections in the U.S.

    SBC: NANOSHELL COMPANY, LLC            Topic: N/A

    Lectin recognition of fungal cell wall polysaccharides will be used to develop a rapid screening chip technology for the detection endemic fungal infection in blood. Fungal infections are life threatening to immune-compromised and immuno-suppressed patients (i.e. premature and malnourished infants, AIDS and cancer patients. seniors, and organ donation recipients). In addition to routine screenin ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. SMARxT Med Reminder Plus system to Improve Patient Medication Adherence

    SBC: Concordance Health Solutions, Inc.            Topic: NIA

    Project Abstract Concordance Health Solutions (CHS) is an Indiana company with a mission to improve patient medication adherence in partnership with pharmacists and other healthcare providers. With this SBIR grant, CHS will develop and test an innovative product, the SMARxT Med Reminder (SMR) Plus system, which will extend the capability of the inexpensive SMARxT Med Reminder cap developed with a ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. A Quantum Similarity Approach for the Discovery of Anti-Trypanosome Drug Leads

    SBC: GRADIENT BIOMODELING, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Human African trypanosomiasis (HAT) is an infectious disease with a large global health burden occurring primarily in Central and Eastern Africa. HAT is 100% fatal if untreated and the current drug therapies suffer frompoor safety profiles, difficult treatment regimens, limited effectiveness, and high costs. Furthermore, drugs that cross the blood brain barrier ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Multiplexed Ovarian Cancer Microfluidic Tissue Microarray

    SBC: Carterra, Inc.            Topic: NCI

    Project Summary We propose an instrument system for automated, multiplexed cell- and tissue-based experiments (i.e. tissue microarrays) called the Microfluidic Flow Cell Array (MFCA). The MFCA consists of a microfluidic flow cell array integrated with an inverted fluorescent microscope, allowing the observation of 48 flow chambers simultaneously or an individual chamber at higher magnification. Th ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. The Development of Novel Inhibitors of BCL2 Gene Expression as Anticancer Therape

    SBC: TETRAGENE, LLC            Topic: NCI

    Project Summary Evasion of apoptosis is a hallmark of cancer and is associated with oncogenesis, tumor maintenance, and resistance to conventional chemotherapy. BCL-2 was the first identified anti-apoptotic factor and is a member of the BCL-2 family of proteins that cooperate in the regulation of programmed cell death. BCL-2 plays a dominant role in the survival of multiple lymphoid malignancies a ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Immune-based brain cancer diagnostic for rapid, accurate disease classification

    SBC: HealthTell Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Accurate, early disease diagnosis and monitoring are critical aspects to effective prevention, treatment, and remission of disease. Most diagnostic methods available today are not simple or sensitive enough to significantly impact patients' response to treatment or survival outcome. This unmet need is highlighted by diseases, such as brain cancers, that o ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Targeting ether lipid biosynthesis for disease

    SBC: ECHELON BIOSCIENCES, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Cancer is a significant health burden in the US and across the globe, representing the second leading cause of death in the US. Cancer cells have metabolic pathways that are altered significantly compared to normal cells. As a result, the pathways involved (lipid biosynthesis for example) are considered excellent targets for therapeutic intervention. The levels ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Glycosaminoglycans to Treat and Prevent Radiation-Induced Oral Mucositis

    SBC: GLYCOMIRA, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): GlycoMira Therapeutics has developed safe and effective anti-inflammatory glycosaminoglycan derivatives and proposes to test the feasibility of using its lead compound to treat or prevent oral mucositis. Mucositis is acommon and debilitating complication of cancer treatment. Cancer patients undergoing radiation or chemotherapy often develop this painful inflam ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services
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