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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Improving Data, Improving Care, Making it Count, Integration Toolkit for Eliminating Double Data Entry

    SBC: Hdox Bioinformatics Inc.            Topic: N/A

    Phase II goals will be to: 1. To develop a production version of an Integration toolkit (ITK) that can deployed at low cost to clinics using spina bifida EMR (to improve the efficiency of their participation in the NSBPR) 2. To pilot the ITK at selected SB-EMR clinics 3. To evaluate the impact of the production version of the ITK The ITK will be developed based on design principles & specifica ...

    SBIR Phase II 2014 Department of Health and Human Services
  2. Rapid Detection of Endemic Fungal Infections in the U.S.

    SBC: NANOSHELL COMPANY, LLC            Topic: N/A

    Lectin recognition of fungal cell wall polysaccharides will be used to develop a rapid screening chip technology for the detection endemic fungal infection in blood. Fungal infections are life threatening to immune-compromised and immuno-suppressed patients (i.e. premature and malnourished infants, AIDS and cancer patients. seniors, and organ donation recipients). In addition to routine screenin ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Innate Defense Regulator Peptide as a Therapeutic for Acute Pneumonic Melioidosis

    SBC: Soligenix, Inc            Topic: NIAID

    DESCRIPTION (provided by applicant): This proposal describes development of an immunomodulatory peptide that targets the host defense system for treatment of acute pneumonic melioidosis. The disease is caused by Burkholderia pseudomallei (Bps), a non-spore-forming motile saprophytic bacterium that can be transmitted from the soil to humans by inhalation, through cuts in the skin and by ingestion. ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Increasing viability of lung organs for transplantation

    SBC: TRIM-EDICINE, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): While organ transplantation is a vital last resort therapy to treat patients with end-organ failure of the lung there is a growing waiting list of patients who are eligible for transplants as the number of suitable donor organs fall far short of the demand for these lifesaving procedures. Improving the preservation of donated organs so that a greater percentage ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. A Quantum Similarity Approach for the Discovery of Anti-Trypanosome Drug Leads

    SBC: GRADIENT BIOMODELING, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Human African trypanosomiasis (HAT) is an infectious disease with a large global health burden occurring primarily in Central and Eastern Africa. HAT is 100% fatal if untreated and the current drug therapies suffer frompoor safety profiles, difficult treatment regimens, limited effectiveness, and high costs. Furthermore, drugs that cross the blood brain barrier ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. TRAIL Upregulation by TIC10 Analogs

    SBC: PROVID PHARMACEUTICALS INC.            Topic: NCI

    Project Summary/Abstract TIC10 (ONC201) is a first-in-class antitumor agent and small molecule inducer of the TRAIL gene which was identified in a high-throughput small molecule library screen in the lab of our collaborator, Dr. Wafik El-Deiry at Penn State University and has been shown to have preclinical efficacy in several difficult-to-treat disease settings that include unmet clinical needs su ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Multiplexed Ovarian Cancer Microfluidic Tissue Microarray

    SBC: Carterra, Inc.            Topic: NCI

    Project Summary We propose an instrument system for automated, multiplexed cell- and tissue-based experiments (i.e. tissue microarrays) called the Microfluidic Flow Cell Array (MFCA). The MFCA consists of a microfluidic flow cell array integrated with an inverted fluorescent microscope, allowing the observation of 48 flow chambers simultaneously or an individual chamber at higher magnification. Th ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. The Development of Novel Inhibitors of BCL2 Gene Expression as Anticancer Therape

    SBC: TETRAGENE, LLC            Topic: NCI

    Project Summary Evasion of apoptosis is a hallmark of cancer and is associated with oncogenesis, tumor maintenance, and resistance to conventional chemotherapy. BCL-2 was the first identified anti-apoptotic factor and is a member of the BCL-2 family of proteins that cooperate in the regulation of programmed cell death. BCL-2 plays a dominant role in the survival of multiple lymphoid malignancies a ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Development of Novel Fast GPU Monte Carlo and Active Photonics Simulation Softwar

    SBC: SIMPHOTEK, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Photodynamic therapy (PDT) is used for treating a variety of medical conditions including cancer. Even after many years of PDT research and the large-scale use of PDT treatments by physicians, there are many aspects ofPDT, such as quantitative predictions for diffusive light propagation and the kinetics of the light-material interactions, that are not well unde ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Immune-based brain cancer diagnostic for rapid, accurate disease classification

    SBC: HealthTell Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Accurate, early disease diagnosis and monitoring are critical aspects to effective prevention, treatment, and remission of disease. Most diagnostic methods available today are not simple or sensitive enough to significantly impact patients' response to treatment or survival outcome. This unmet need is highlighted by diseases, such as brain cancers, that o ...

    SBIR Phase I 2014 Department of Health and Human Services
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