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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Pedestrian Auto Enforcement Program (PAEP)

    SBC: Polaris Sensor Technologies, Inc.            Topic: 122FH3

    The Pedestrian Automated System for Enforcement and Safety is a novel video and radar based system that is able to detect and track vehicles and pedestrians, and to determine when violations of pedestrian right of way have occurred. By using multiple sensor modalities the system provides a robust tracking solution. The use of radar provides long standoff detection and tracking of vehicles with hig ...

    SBIR Phase II 2014 Department of Transportation
  2. Endotoxin Neutralization as a Biomonitor for HIV Disease Progression

    SBC: BIODTECH, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Endotoxin neutralization in human plasma is an excellent indicator of chronic immune activation, which is the most accurate predictor of mortality in HIV. Recently we developed an assay using endotoxin neutralization asan indicator of bacterial translocation. This assay is accurate in discriminating control patients from those with inflammatory bowel disease in ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. New High Throughput Anti-Tumor Drug Screening System

    SBC: Vivo Biosciences Inc            Topic: NCI

    DESCRIPTION (provided by applicant): This SBIR project is focused to develop, validate and commercialize an advanced high-throughput anti- tumor drug screening platform (HTS) which employs a new 3D HuBioGEM assay technology. Preclinical drug screening is commonly performed using biochemical and cell-based assay systems. In recent years, more relevant 3D spheroid models have been developed using mi ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Chronically Acting CFTR Inhibitor Discovery for Secretory Diarrhea and ADPKD

    SBC: DISCOVERYBIOMED, INC.            Topic: NIDDK

    Project Summary Abstract DiscoveryBioMed, Inc. (DBM) has launched an innovative and automation-friendly drug discovery program to screen a collection of small molecular compounds on a human epithelial cell platform expressing physiologically relevant levels of the wild-type Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) to discover a new class of therapeutic drugs for secretory disease ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Inter-alpha-inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. IGF::OT::IGF SBIR Phase I: SynVivo-Tumor: A Physiological 3D Model of the Tumor Microenvironment

    SBC: CFD Research Corporation            Topic: NCI

    Not Available

    SBIR Phase I 2014 Department of Health and Human Services
  8. IGF::OT::IGF High-Impact Substance Abuse Prevention Technologies. SBIR Phase I. Period of Performance 7/16/2014-1/15/2015

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    The overarching objective of this project is to develop an innovative technological tool that will facilitate the implementation of an evidence-based substance abuse prevention program and related health behavior risk programs among military personnel. PUBLIC HEALTH RELEVANCE

    SBIR Phase I 2014 Department of Health and Human Services
  9. DBM Anti-Proliferative Lead Small Molecules for Polycystic Kidney Disease

    SBC: DISCOVERYBIOMED, INC.            Topic: 400

    DESCRIPTION provided by applicant An important discovery and validation event occurred recently within human cell based drug discovery programs at DiscoveryBioMed Inc DBM yielding a lead class of cytostatic anti proliferative small molecules that display nanomolar potency and marked efficacy against hyperproliferative human PKD cells that create and line remodeled PKD cysts within emergen ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Polarization Enhanced Thermal (eTherm) Imager for Mobile Footprint Detection

    SBC: Polaris Sensor Technologies, Inc.            Topic: HSB0141001

    Imaging polarimetry has demonstrated the ability for detection of military targets in situations where traditional imaging sensors fall short. Detection of polarization of light emitted or reflected from objects in a scene enhances contrast between objects and backgrounds, providing additional information about the geometry, material, temperature, and surface characteristics of the objects in the ...

    SBIR Phase I 2014 Department of Homeland Security

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