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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Robust and Sustainable Utilization of Biofuel Co-products to Increase Biorefinery Diversification

    SBC: MARC IV CONSULTING INC            Topic: 88

    In this project, researchers will evaluate the potential for utilizing biofuel co-products for high value biobased materials. The two key biobased materials that will be investigated are glycerol carbonate and sucrose esters. The goal of the project is to develop commercially viable, energy efficient routes for these biobased materials using enzymatic catalysis and solvent free conditions. Glycero ...

    SBIR Phase I 2014 Department of Agriculture
  2. Development of Anti-Microbial Peptide Therapeutics

    SBC: TENSIVE CONTROLS, INC.            Topic: 83

    A safe food supply is critical to the well being of any society. However, in highly urbanized societies, the number of people affected by a contaminated food source can be huge. Antibiotic resistant disease in the U.S. is an escalating problem [2, 3]. Much of this problem is a result of the use of antibiotics in production animals, where they prevent disease. Chronic use results in the emergence o ...

    SBIR Phase I 2014 Department of Agriculture
  3. Development of Iron Phosphate Wasteforms for Fission Products Waste Streams

    SBC: MO-SCI Corp.            Topic: 19g

    Most liquid high-level nuclear waste is currently being immobilized to a solid form as a borosilicate glass by vitrification. However, many nuclear wastes have complex and diverse chemical compositions that reduce their compatibility with borosilicate glass. The current baseline spent nuclear fuel reprocess generates secondary waste streams that generally include large amounts of MoO3 and lanthani ...

    SBIR Phase I 2014 Department of Energy
  4. Low-Cost, High Efficiency Integration of Solid-State Lighting and Building Controls Using a Packet Energy Transfer (PET) Power Distribution System

    SBC: VoltServer            Topic: 03a

    Solid state lighting has not yet taken off in commercial buildings due to its high relative installed cost. On a normalized basis, solid state lighting replacement lamps are on the order of two times more expensive than equivalent compact fluorescent lamps (CFLs), and five times more expensive than an equivalent downlight fixture. An additional barrier relates to the performance and cost of the dr ...

    SBIR Phase I 2014 Department of Energy
  5. Development of Cost-Effective YSZ Coating Methods for SOFC Interconnects

    SBC: MO-SCI Corp.            Topic: 14b

    Solid oxide fuel cells (SOFCs) require robust seals that can prevent intermixing of air and fuel, remain inert in reducing and oxidizing environments while in contact with SOFC materials, and maintain their effectiveness through repeated thermal cycles. Recent research has focused on compliant (or viscous) glasses that remain vitreous over time in the SOFC stack operating environment, and are able ...

    STTR Phase I 2014 Department of Energy
  6. Development of TAK1 Compounds for Neonatal Onset Multisystem Inflammatory Disease

    SBC: CONFLUENCE LIFE SCIENCES, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): Cryopyrin-associated periodic syndromes (CAPS) are a family of rare autoinflammatory diseases of which neonatal-onset multisystem inflammatory disease (NOMID) is the most severe phenotype. NOMID is characterized by NLRP3 activating mutations resulting in excessive interleukin- 1?IL-1?and IL-18 production associated with recurrent fever, rash, skeletal lesions, ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. AAAPT Technology for Improving Chemotherapy

    SBC: Sci-Engi-Medco Solutions, Inc            Topic: NCI

    DESCRIPTION provided by applicant Dysregulation of apoptosis pathways and loss of Human Beta Defensin hBD are the common tactics adapted by cancer cells to circumvent the effects of chemotherapy Consequently high dose of chemotherapy is required to obtain a clinically relevant therapeutic index which in turn compromises safety and develops resistance to therapy The problem is acute p ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Developing a standardized kit and normal reference profile for circular RNAs in the nervous system

    SBC: COFACTOR GENOMICS, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): Modified ribonucleic acids (RNA) are important regulators of translation and other cellular pathways. Non- coding RNAs like microRNAs play significant roles in neuronal development, and can serve as biomarkers for psychiatric disorders. Another such modified RNA is circular RNA (circRNA), a non-coding transcript present in the cytoplasm. Since circRNAs are pres ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. A new two-drug combination therapy for noise-induced hearing loss

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    DESCRIPTION (provided by applicant): Noise is the most common occupational and environmental hazard, thus it is not surprising that noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit, second only to age-related hearing loss (presbycusis). Although therapeutics that target the free radical pathway have shown promise for reducing NIHL, there are no FDA- ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services

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