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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Inter-alpha-inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. IGF::OT::IGF High-Impact Substance Abuse Prevention Technologies. SBIR Phase I. Period of Performance 7/16/2014-1/15/2015

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    The overarching objective of this project is to develop an innovative technological tool that will facilitate the implementation of an evidence-based substance abuse prevention program and related health behavior risk programs among military personnel. PUBLIC HEALTH RELEVANCE

    SBIR Phase I 2014 Department of Health and Human Services
  4. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing

    SBC: BCR DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): BCR Diagnostics, Inc. (BCR) has recently developed and patented a technology platform for engineering fluorogenic functionality into living Bacillus spores. Fluorogenic spores (F-spores) produced at BCR appear to be phy siologically identical to normal spores except for performing as self reporters of initial germination events. Considering the unique features ...

    SBIR Phase II 2008 Department of Health and Human Services
  5. T1D Tolerance Induction with Natural Treg Epitopes

    SBC: EPIVAX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Type 1 (juvenile) diabetes is an organ-specific autoimmune disease resulting from destruction of insulinproducing pancreatic beta-cells. In non-diabetics, islet cell antigen-specific T cells are either deleted in thymic development or are converted to T regulatory cells that actively suppress effector responses to islet cell antigens. In juvenile diabetics and ...

    SBIR Phase I 2008 Department of Health and Human Services
  6. High Content Drug Screening with Cardiac Tissue

    SBC: MYOMICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Myomics, Inc. has developed High Content Drug Screening (HCS) technology for in vitro testing of compounds which alter contractile forces generated by miniaturized tissue engineered organs (Myo-Force Assay SystemTM, MFA STM). Myomics' 3-D tissue/force sensor composite is capable of long term studies (1-4 weeks) and provides force as well as electrophysiological ...

    SBIR Phase I 2008 Department of Health and Human Services
  7. A Stage-Based Expert System for Teen Dating Violence Prevention

    SBC: Pro-Change Behavior Systems Inc            Topic: N/A

    Location P.O. BOX 755 02892 WEST KINGSTON, RI United States 41° 29' 0.2256" N, 71° 33' 11.6244" W Rhode Island US 9R44MH086129-02A1 $748 985.00 2 008 A Stage-Based Expert System for Teen Dating Violence Prevention Department of Health ...

    SBIR Phase II 2008 Department of Health and Human Services

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