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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Inter-alpha-inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. FASTCOUNT Next generation stereology platform for fast, accurate 3D cell counting

    SBC: MICROBRIGHTFIELD, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): Stereologic cell counting has revolutionized the field of neuroscience over the last 20 years, and numerous studies highlighting the impact of stereologic cell counting in basic neuroscience and pharmaceutical and biotechnology research continue to be published. A single study, however, may take months since investigators must decide by visual inspection whethe ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Development and wear testing of bi-material bearing surfaces for hip arthroplasty

    SBC: CORNERSTONE PARTNERS, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): Hip replacement surgery is a tremendously effective and successful treatment for patients suffering from degenerative joint disease. However, revision surgery accounts for about 13% of hip implant surgeries in the U.S.,costing 3 billion annually and presenting significantly increased morbidity and risk of complication for patients. Wear and/or failure of total ...

    STTR Phase I 2014 Department of Health and Human Services
  5. IGF::OT::IGF High-Impact Substance Abuse Prevention Technologies. SBIR Phase I. Period of Performance 7/16/2014-1/15/2015

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    The overarching objective of this project is to develop an innovative technological tool that will facilitate the implementation of an evidence-based substance abuse prevention program and related health behavior risk programs among military personnel. PUBLIC HEALTH RELEVANCE

    SBIR Phase I 2014 Department of Health and Human Services
  6. 3D Virtual Slide System for Creation and Analysis of Focusable Digital Slides

    SBC: MICROBRIGHTFIELD, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): This project aims to develop a novel system, Biolucida AT, which will greatly enhance the use of array tomography, the state-of-the-art method for investigating synaptic plasticity at the molecular level in human postmortem research and animal models of psychiatric, neurological and childhood developmental disorders. Synaptic transmission is essential for centr ...

    SBIR Phase II 2014 Department of Health and Human Services
  7. 3D Virtual Slide System for Creation and Analysis of Focusable Digital Slides

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    DESCRIPTION provided by applicant This project aims to develop a novel system Biolucida AT which will greatly enhance the use of array tomography the state of the art method for investigating synaptic plasticity at the molecular level in human postmortem research and animal models of psychiatric neurological and childhood developmental disorders Synaptic transmission is essential for centr ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Integration of Complex Geometry, 3D Woven Preforms via Innovative Stitching Technique

    SBC: T.E.A.M., INC.            Topic: H701

    Thick, 3D woven carbon/phenolic composites offer potential improvement over legacy thermal protection systems (TPS) for re-entry vehicle heat shield applications. However due to the scale and complexity of typical re-entry vehicle structures, it is likely that multiple 3D woven panels would need to laid up to create the overall heat shield, creating a potential weak spots at the panel joints. ...

    SBIR Phase I 2014 National Aeronautics and Space Administration
  9. Advancing High Energy Lithium-Sulfur Batteries

    SBC: Yardney Technical Products, Inc.            Topic: Z102

    Lithium-Ion batteries have been a main source of energy for many aerospace applications over the past decade. Future space missions are facing a number of challenging requirements, including significant increase in specific energy, approaching 500 Wh/kg, and energy density of 700 Wh/l at cell level. Compared to state-of-the-art technology today, a reduction in mass and volume are necessary, along ...

    SBIR Phase I 2014 National Aeronautics and Space Administration
  10. Inlet Cover Treatment to Enhance Zero NPSH Inducer Operation

    SBC: Concepts NREC, LLC            Topic: H203

    Zero net positive suction head (NPSH)-capable hydrogen pump inducers are a critical component needed to lower the cost and increase the effectiveness of Nuclear Thermal Propulsion (NTP) engines. Zero NPSH pumps need to be able to pump up to 55% vapor fraction by volume without significant head fall-off. Current technology inducers can pump liquid hydrogen up to a limit of about 25% vapor fractio ...

    SBIR Phase I 2014 National Aeronautics and Space Administration

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