Award Data

This SBIR Phase I project will benefit society by reducing the cost of manufacturing biologic pharmaceuticals and improving their quality, including pharmaceuticals that are currently too costly to manufacture because they target relatively small patient populations. The proposed innovation will advance state-of-the-art by providing a continuous in-situ multi-analyte sensor enabling novel methods ...

This Small Business Technology Transfer Phase I project will develop advanced tools for semiconductor metrology that are essential for high accuracy at finer resolution as progress continues to the finer lithography nodes. This progress is essential to satisfy the demand for greater performance in numerous consumer products as well as many other applications. The intellectual merit of this project ...

Abstract All therapeutic antibodies and most vaccines critically depend on the ability of antibodies to specifically recognize particular antigens consequently detailed characterization of antibody antigen binding can provide invaluable information to understand and guide development Unfortunately due to the time and expense required atomic resolution structure determination is typically use ...

Development of a DNA Aptamer Based Electrochemical Assay for Acetazolamide in Urine Using a Handheld Biosensor for Compliance Validation in Clinical Drug Trials Thirty to over eighty percent of patients enrolled in pharmaceutical clinical trials do not comply with trial protocols by discarding the drug under investigation or not using the proper dosages This common practice compromises the medica ...

The purpose of this SBIR Proposal is to conduct the research needed to enable blockchain technology to serve as serve as a decentralized foundation for privacy-respecting identity management. In this phase, Evernym will research and develop a decentralized key management system (DKMS) based on the DID (Decentralized Identifier) specification developed in Phase I. The DID specification has already ...

ABSTRACT TessaTM is validated medical device wearable capable of providing clinical sleep quality metrics for multiple nights to assess the efficacy of a sleep disorder treatment Tessa records the forehead EEG to stage sleep in an automated report that tracks changes in sleep architecture before and after a treatment for many sleep disorders such as obstructive sleep apnea and insomnia There is ...

PROJECT SUMMARYABSTRACT Lower urinary tract symptomsLUTSis one of the most common medical problems among older menaffectingof men by the time they reachyears of age andby the time they reach the age ofLUTS is a progressive disease that has been shown to significantly increase the risk of depression and reduce quality of lifeDue to thisearly detection and active management of LUTS is criticalUroflo ...

PROJECT SUMMARYAcute lung injuryALIand acute respiratory distress syndromeARDSresult from a common pathogenic processpulmonary injury or infection triggers an overwhelming inflammatory responsecytokine stormthat results in increased endothelial and epithelial permeability and efflux of inflammatory cellsproteinand water from the vascular system into the alveolar spaceThe further release of inflamm ...

A significant problem in the automotive industry is the complexity of setting up and running Finite Element Analysis (FEA) simulations for various aspects of a design. Translating Computer-Aided Design (CAD) models to FEA models is an error-prone process commonly performed by expert users. Consequently, the FEA simulation is often relegated to the end of the design process as a “pass/fail” tes ...

Advanced modeling and simulation software, such as the Uintah Computational Framework, has been developed in the US, in part, through significant funding by the Department of Energy Office of Advanced Scientific Computing. This software, as well as similar advanced simulation software, requires expert users and high performance computing systems to effectively utilize them, which has resulted in u ...