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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel approaches to extending glucose sensor lifespan

    SBC: AEGIS BIOSCIENCES, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Long term transcutaneous devices such as catheters; require patients to endure extended skin breaches (wounds) that can be difficult to manage clinically, i.e. infection and inflammation. These complications not only shorten device lifespan, but also compromise patient health. In the case of short-term commercial transcutaneous glucose sensors, FDA has approved ...

    SBIR Phase I 2009 Department of Health and Human Services
  2. Development of a humanized anti-CD47 antibody for treatment of tissue ischemia.

    SBC: VASCULOX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Nitric oxide (NO) is a critical regulator of cardiovascular physiology, coordinating the activities of the endothelium, the vessel wall and circulating cells to optimize the flow of blood and oxygen to tissues. Increasing the bioavailability of NO should provide therapeutic benefit in the treatment of many diseases ascribed to insufficient NO bioavailability. A ...

    STTR Phase I 2009 Department of Health and Human Services
  3. Treatment of Transplant Reperfusion with an Anti-CD47 Antibody

    SBC: VASCULOX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Organ transplantation is one of the great success stories of modern medicine. However, the supply of suitable organs lags far behind the need and many patients die while waitlisted for organs. Current practice involves donor preconditioning to stabilize organs and tissues for transplant in attempts to increase the supply of donor organs acceptable for transpl ...

    SBIR Phase I 2009 Department of Health and Human Services
  4. Pandemic H5N1 vaccine containing recombinant H5 and a synthetic TLR4 agonist, GLA

    SBC: TRIA BIOSCIENCE CORP.            Topic: N/A

    DESCRIPTION (provided by applicant): H5N1 is a highly pathogenic avian influenza virus that can cause severe disease and death in humans. H5N1 is spreading rapidly in bird populations world-wide and there is great concern that this virus will begin to transmit between people and cause a global pandemic catastrophe. Vaccines are the cornerstone strategy for combating avian flu but there are numerou ...

    SBIR Phase I 2009 Department of Health and Human Services
  5. Adjunctive Use of Apyrase to Fibrinolytic Therapy

    SBC: APT THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for treatment of acute myocardial infarction. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics approach, we have successfully engineered human apyrases which exhibit both antiplatelet and anti-inflammatory activities. With the Phase I gran ...

    SBIR Phase I 2009 Department of Health and Human Services
  6. Developing an Evidence-Based Intervention Planning System for Obesity Prevention

    SBC: TRANSTRIA, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): To increase the effectiveness of chronic disease prevention and health promotion interventions, researchers and practitioners must work collaboratively to ensure that evidence-based approaches are translated into publicly accessible tools and resources. To disseminate evidence-based intervention strategies, it is essential to summarize the associated processes, ...

    SBIR Phase I 2009 Department of Health and Human Services
  7. Thermally Targeted Delivery of Therapeutic Peptides

    SBC: Thermally Targeted Therapeutics, Incorporated            Topic: N/A

    DESCRIPTION (provided by applicant): Current treatment of solid tumors is limited by normal tissue tolerance, inherent tumor resistance to radiation or chemotherapy, and toxicity from systemic administration of antineoplastic agents. The result is a narrow therapeutic index for most current chemotherapeutic agents. Our long term goal is to overcome these limitations by developing a targeted therap ...

    SBIR Phase I 2009 Department of Health and Human Services
  8. A Therapeutic Agent for Radiation-induced Lung Fibrosis

    SBC: AUXAGEN, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Lung fibrosis, a group of incurable lung diseases with high mortality rates, is characterized by inflammatory cell infiltration, fibroblast proliferation, and excessive deposition of extracellular matrix proteins (ECM) in lung parenchyma. Globally, five million people are affected by lung fibrosis. In the U.S. alone, 200,000 suffer from this disease. Of these m ...

    SBIR Phase I 2009 Department of Health and Human Services
  9. Online Training in the Fundamentals of Eating Disorders Treatment

    SBC: BEHAVIORAL TECH RESEARCH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This is a Phase I Small Business Innovation Research (SBIR) grant application to support the development of an innovative, online training program to aid in the dissemination of evidence-based Eating Disorder (ED) treatments (e.g., Cognitive Behavioral Therapy and Interpersonal Psychotherapy for Bulimia Nervosa (BN) and Binge Eating Disorder (BED) . The current ...

    SBIR Phase I 2009 Department of Health and Human Services
  10. DBT Skills Training Central

    SBC: BEHAVIORAL TECH RESEARCH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This is a Phase I Small Business Innovation Research (SBIR) grant application to support the development of an innovative, online training aid for Dialectical Behavior Therapy (DBT) skills providers treating borderline personality disorder and substance dependence (BPD-SUD) individuals. The primary purpose of the eventual product, DBT Skills Central, is to help ...

    SBIR Phase I 2009 Department of Health and Human Services

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