Award Data

Design and evaluate components for a new device for remotely releasing electronic tags that have been attached to marine animals with a focus on a novel approach for the release mechanism. Current methods for releasing tags include corrodible metal pins and mechanical devices for cutting plastic or steel wires. These methods are less reliable because the attachment wires and pins may prematurely ...

DESCRIPTION (provided by applicant): Long term transcutaneous devices such as catheters; require patients to endure extended skin breaches (wounds) that can be difficult to manage clinically, i.e. infection and inflammation. These complications not only shorten device lifespan, but also compromise patient health. In the case of short-term commercial transcutaneous glucose sensors, FDA has approved ...

The SBIR Phase I proposal is designed to improve the high end temperature performance of Altairnano''''s nano Lithium titanate batteries and will develop an equivalent circuit model capturing the transient dynamics of Altairnano’s 50 Ah cell. Altairnano will study the effects of various materials and the interactions between them to determine the best electrode material combination in order to e ...

DESCRIPTION (provided by applicant): Nitric oxide (NO) is a critical regulator of cardiovascular physiology, coordinating the activities of the endothelium, the vessel wall and circulating cells to optimize the flow of blood and oxygen to tissues. Increasing the bioavailability of NO should provide therapeutic benefit in the treatment of many diseases ascribed to insufficient NO bioavailability. A ...

DESCRIPTION (provided by applicant): Organ transplantation is one of the great success stories of modern medicine. However, the supply of suitable organs lags far behind the need and many patients die while waitlisted for organs. Current practice involves donor preconditioning to stabilize organs and tissues for transplant in attempts to increase the supply of donor organs acceptable for transpl ...

Andrews Space, Inc. proposes to test new high energy density propellant combinations and conduct a feasibility study on their applications. These propellants are enablers for use in high performance tactical missiles, high delta-V single stage vehicles such as a suborbital point to point vehicles, and compact high energy upper stages. Our Phase I approach is to develop stage and vehicle designs ...

The proposed approach for Phase I of this effort brings together two key items that are needed to work in concert with one another: advanced fatigue assessment methods and non-destructive inspection & detection techniques. Successful synthesis of these elements and the engineering disciplines behind them will provide an optimized and advanced method of taking full advantage of engineered residual ...

DESCRIPTION (provided by applicant): H5N1 is a highly pathogenic avian influenza virus that can cause severe disease and death in humans. H5N1 is spreading rapidly in bird populations world-wide and there is great concern that this virus will begin to transmit between people and cause a global pandemic catastrophe. Vaccines are the cornerstone strategy for combating avian flu but there are numerou ...

DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for treatment of acute myocardial infarction. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics approach, we have successfully engineered human apyrases which exhibit both antiplatelet and anti-inflammatory activities. With the Phase I gran ...

DESCRIPTION (provided by applicant): To increase the effectiveness of chronic disease prevention and health promotion interventions, researchers and practitioners must work collaboratively to ensure that evidence-based approaches are translated into publicly accessible tools and resources. To disseminate evidence-based intervention strategies, it is essential to summarize the associated processes, ...