Award Data

DESCRIPTION (provided by applicant): Nearly half of all college students have a diagnosable mental health problem (Blanco et al., 2008). College counseling centers (CCCs) are faced with increasing demands for services from Universities, students and parents to meet the treatment needs of their students (Beamish, 2005), in the context of increasingly severe cases and declining resources (Gallagher, ...

DESCRIPTION (provided by applicant): We seek to develop an ultra-fast, zinc-free insulin analog formulation for the treatment of diabetes mellitus. An ultra-fast pharmacokinetic-dynamic (PK/PD) profile promises to enable superior performance of pump therapy (continuous subcutaneous insulin infusion) with enhanced safety and more robust integration with glucose- sensing technologies. Ultra-fast kin ...

DESCRIPTION (provided by applicant): If successful, this program will result in an assay chip that collects, stabilizes, and accurately quantifies a suite of biomarkers indicative of renal injury. Its sensitivity and accuracy may enable it to detect slowlyoccurring renal damage. Its multianalyte capability could distinguish different mechanisms of renal damage. It should be adaptable to automated ...

DESCRIPTION (provided by applicant): The US Center for Disease Control (CDC) estimates that more than 1.7 million healthcare associated infections (HAI) are acquired in US hospitals every year, resulting in approximately 100,000 deaths and adding 30-40 billion of direct treatment expense to the nation's healthcare costs (1). Microbial pathogens from tap water are a significant source of HAI ...

DESCRIPTION (provided by applicant): Although obstructive sleep apnea has received the lion's share of recognition and investigation in research and practice, more troubling forms of sleep apnea, like those that are mediated by chemoreflex instability, exist and continue to have inadequate treatment. Central apneas and periodic breathing (now called the Cheyne Stokes breathing pattern) are th ...

DESCRIPTION (provided by applicant): The goal of the proposed project is to develop and validate a new device capable of recording the respiratory airflow without the need for a pressure cannula, thermal sensor or other sensor being attached to a patient'sface. This new device will address the problem of patients not tolerating or inadvertently removing the sensor from their face while they t ...

DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess Kinesia-D , a compact, portable, wireless movement disorder system with continuous monitoring capabilities to detect and quantify the severity of levodopa-inducedchoreatic dyskinesia, or irregular rapid involuntary movements, in Parkinson's disease (PD). Disease incidence affects over 1,000,000 peopl ...

DESCRIPTION (provided by applicant): The purpose of the present SBIR Phase 1 feasibility study is to assess the efficacy of our selective dopamine (DA) transport inhibitor PD2005 in improving cognitive deficits associated with traumatic brain injury (TBI).Executive function deficits like short term or working memory, processing speed, and attention are commonly prevalent in TBI patients. TBI-assoc ...

DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess Kinesia-HS, an integrated solution to facilitate pharmaceutical development of neuroprotective interventions targeted to Parkinson's disease (PD). The systemwill include both compact patient-worn instrumentation and web-based infrastructure for home monitoring to provide significantly increased m ...

DESCRIPTION (provided by applicant): Cerebral edema (CE, or brain swelling) is a major contributor to the damage caused by stroke, traumatic brain injury, and bacterial meningitis. Stroke alone is the third leading cause of death in the USA and the leadingcause of disability. Unfortunately, few treatment options are available for CE, and these are of limited efficacy. Central in the development of ...