Award Data

This proposal addresses the development and use of lightweight, low thermal-capacity reformable tooling materials for high-temperature composite processing evaluation, parts prototyping, trial production and full-rate production of PMC engine components. The weight-saving promise of high-temperature polymer matrix composites (PMCs) for engine components is offset by the very high costs of parts m ...

This Small Business Technology Transfer (STTR) Phase I project will demonstrate the feasibility of a two-phase controllable flow in microchannels. The fluid consists of a carrier fluid, nano-magnetic particles, and additives. The proposed work will also produce low-cost, nano-magnetic particles using a novel scaled-up synthesis process. The objectives of the proposed research are to design a large ...

This Small Business Innovative Research (SBIR) Phase I project demonstrates the feasibility of producing stearidonic acid from microalgae for human consumption to combat cardiovascular diseases (CVD). The cardiovascular benefits of fish oil enriched in omega-3 polyunsaturated fatty acids (n-3 PUFAs) are well-documented. Despite overwhelming evidence and strong recommendations supporting the health ...

DESCRIPTION (provided by applicant): Chronic, neuropathic pain is one of the most important unmet medical needs in the United States, affecting tens to hundreds of millions of people nationwide at some time during their lives. Novel therapeutic approaches are desperately needed. The brain peptides neurotensin (NT) and its fully active derivative NT[8- 13] have been shown to exhibit considerable, l ...

Baldwin Environmental Inc. (BEI) successfully completed an SBIR Phase I project that demonstrated the feasibility of designing and producing a Fine and Coarse Particulate Monitoring System (FCPMCEMS). This system simultaneously measures and reports mass concentrations of fine and coarse particulate material using Atmospheric Dispersion Simulation and Beta Attenuation Monitoring (BAM). A design a ...

This Small Business Technology Transfer (STTR) Phase I project aims at developing new material growth technology for manufacturing semiconductor substrates of cubic 3C-SiC polytype for high-power, high-frequency, high-temperature, and high-radiation hardness military, space, and commercial applications. The new process for SiC epitaxial growth utilizes novel mechanisms of gas phase and surface rea ...

Recreation trails are a key component of the social, economic and health of rural communities. People with mobility impairments are often excluded from trails, shared-use paths, parks and other public areas where barriers are erected to prevent access by motorized trail vehicles (MTVs), to control livestock or wildlife, as an access point in a fenced area, or for a variety of other reasons. Many p ...

DESCRIPTION (provided by applicant): Assays are being developed in efforts to reduce the number of animals required for research. In particular, cell based systems that can evaluate a variety of compounds and/or screen single compounds with many cell types would provide the most advantageous platforms. These types of assay systems would be applicable to drug discovery, toxicology testing and envir ...

DESCRIPTION (provided by applicant): Transplantation of islets of Langerhans for the clinical treatment of Type I diabetes has had a resurgence of interest due to results obtained using the "Edmonton protocol". However, at this time, procurement of donor pancreases for islet isolation and transplantation is in its infancy. Most pancreases at more remote donor sites are not procured due to justifie ...

DESCRIPTION (provided by applicant): Allogeneic human heart valves are used in approximately 20% of the tissue heart valve procedures performed annually. Most allogeneic human heart valves (also known as allografts or homografts) are cryopreserved and stored in the vapor phase of liquid nitrogen storage freezers. During shipping from the preservation facility to the surgical point of use, the hear ...