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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 1 - 10 of 5610 results
  1. Adaptive Clinical Efficacy Evaluation of ONC201 in Recurrent High Grade Glioma

    SBC: Oncoceutics, Inc.            Topic: 102

    Project Summary We propose a two arm adaptive Phase II clinical trial to evaluate ONCa selective antagonist of the G protein coupled receptorGPCRdopamine receptor domainDRDin recurrent glioblastomaGBMand diffuse midline glioma associated with very poor prognoses and limited treatment optionsDRDis overexpressed in high grade gliomas and controls Akt ERK signaling pathwaysDownstream of target engage ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. sHLA Protein Chip

    SBC: GENOMICS USA, INC.            Topic: NIAID

    AbstractsHLA Protein ChipThe class IABCand class II HLA proteinsDRBDQDPcomprise the heart of the inducible human immune systemFor organmarrow and stem cell transplantationthe development of serum born antibodies against one or more of those many HLA proteins comprises the best and earliest test for transplant rejectionBecause of the enormous medical importance of transplantationserum testing for t ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Automation and validation of human on a chip systems for drug discovery

    SBC: Hesperos, LLC            Topic: NCATS

    Project Summary AbstractOur overall strategy for Hesperos is to utilize microphysiological systems in combination with functional readouts to establish platforms capable of analysis of chemicals and drug candidates for toxicity and efficacy during pre clinical testingThis is a service based company that is developing low cost in vitro systems containing a novelpumplessmicrophysiological platform a ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Improving drug safety for pregnant women by delivering current and authoritative information via mobile devices

    SBC: RightAnswer.com, Inc.            Topic: NCBDDD

    Project SummaryAbstract! An!estimated!!infants!delivered!annually!in!the!United!States!are!born!with!birth!defects!caused!by!the!use!of! medication!during!pregnancy !!Since!the!peak!prevalence!of!some!diseases !such!as!hypertension !autoimmune!disease ! and!depression !occurs!during!the!childbearing!years !it!is!not!surprising!that!medication!use!during!pregnancy!is! common !with!nine!out!of!ten!p ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Topic 368: Biotherapy of Brain Tumors by Radioiodinated SapC-DOPS Nanovesicles

    SBC: MOLECULAR TARGETING TECHNOLOGIES, INC.            Topic: NCI

    There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. TOPIC 363: myCare2- Supporting Caregivers and Caregiving

    SBC: BRIGHTOUTCOME INC.            Topic: NCI

    The myCare2 solution will be marketed to cancer care organizations and include three separate portals for cancer caregivers, patients and providers. The system will be mobile-enabled and support standards-based EHR integration. Primary myCare2 features include symptom assessment, communication with the care team, care plan dissemination, tailored education content for caregiving and for caregiver ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Topic 364: SysMet: Integrative Systems Metabolomics

    SBC: OmicsCraft LLC            Topic: NCI

    Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. TOPIC 360: A SIMPLE END-TO-END SYSTEM FOR SERIAL CELL SORTING AND MANIPULATION USING A SINGLE CONTAINER

    SBC: DIAGNOLOGIX, LLC            Topic: NCI

    Chemotherapy may control but rarely cure metastatic cancers. Remarkably, modern immunotherapies, including cell-based therapies, have cured metastatic melanomas and other types of cancers. A major challenge for all cell therapies in general is the need to develop cost-effective and efficient manufacturing and delivery capabilities. We have recently established an innovative cell isolation technolo ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. TOPIC 356: FLOUROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: Lucerna Inc.            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Improved Skirt System for Air Cushion Vehicles

    SBC: Materials Sciences LLC            Topic: N171042

    The Navy has challenged the Small Business community to develop an improved skirt system for air cushion vehicles which reduces total ownership cost by increasing product life, decreasing manufacturing costs as well as installation and maintenance time, and improving reparability. The current system is primarily comprised of vulcanized polychloroprene rubber bonded to chemically coated nylon fabri ...

    SBIR Phase I 2018 Department of DefenseNavy

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