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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Phase II Clinical Trial of Lactoferrin in Asthma

    SBC: AGENNIX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The purpose of this research is to determine the efficacy of orally administered recombinant human lactoferrin (rhLF) in Phase II clinical trials in patients with mild to moderate asthma. Asthma is one of the most prevalent chronic inflammatory diseases in the United States affecting approximately 15 percent of the population. Despite intensive research on as ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  2. Ultra Rapid Methods for Streamlined Tissue-to-RT-PCR

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase II proposal aims to simplify, expedite, and stabilize the recovery of high quality RNA from tissue samples. In Phase I, we demonstrated the feasibility of a hands-off, closed tube tissue disruption method termed "MELT" (Multi-Enzymatic Liquefaction of Tissue). MELT enlists potent catabolic enzymes to liquefy tissue within minutes without invasive ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  3. Cost-Effective Manufacturing of Pharmaceutical mRNA

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this proposal is to develop methods for the cost-effective, large-scale synthesis (up to kilograms amounts) of capped, polyadenylated RNA. Several companies are using capped RNA to produce human vaccines against cancers and infectious diseases such as HIV and biowarfare agents. Ambion's patented mMESSAGEmMACHINE(r) kit provides high- ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  4. Enabling RNA Analyses from Formaldehyde-fixed Tissues

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term objectives of this proposal are to permit the isolation of RNA from fixed and imbedded tissues for gene expression analysis. The widespread use of tissue fixation and embedding in both clinical and research settings has resulted in the accumulation of large stores of fixed and embedded tissues in medical schools, hospitals, and universities. The ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  5. Cooled Laser Delivery System: Improved Thermal Therapy

    SBC: Biotex, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The focus of this research is to continue development of a novel interstitial cooled laser delivery system for improved thermal therapy. The system is intended to find applications in the thermal destruction of cancerous tumors. Laser interstitial thermal therapy (LITT) is an ideal method for minimally invasive treatment of localized tumors, but has so far fa ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  6. Interactive Image Guided Closed Loop Thermal Therapy

    SBC: Biotex, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this Phase II Competing Continuation research project is to complete the Phase I clinical trial of a new magnetic resonance imaging guided minimally invasive treatment for focal brain tumors. Over the past four years, BioTex has developed the Visualase(r) thermal therapy system for treatment of localized cancers by using temperature-sensitive mag ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  7. Mandibular Bone transport Reconstruction Plate

    SBC: Custom Scientific            Topic: N/A

    DESCRIPTION (provided by applicant): Surgical excision of hard and soft tissues of the head and neck or high impact trauma can lead to lead to major tissue deficits. Reconstruction of the lower jaw typically involves bone, gingiva, and teeth. Current mandibular distraction devices are used in combination with reconstruction plates, but while the reconstruction plates take the contour of the jaw, t ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a transgenic rat to study brain aging

    SBC: INFLAME THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Neuro-inflammation is thought to be an important factor in age-dependent loss of neuron associated with Alzheimer's disease. We seek STTR funding to develop a unique transgenic rat that serves as a model for chronic neuro-inflammation and age-dependent loss of neurons. Presently, no other animal model offers specific patterns of neuro-inflammation, presence of ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  9. Photofragmentation MS of Ion Mobility Separated Peptides

    SBC: Ionwerks, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Ion mobility (IM) is a perfect instrumental platform for slowing and separating peptide ions-this innovation has enabled efficient VUV photofragmentation (IM-oTOFMS/MS) to be demonstrated in phase I. VUV photofragmentation yields a near perfect technology for "on demand" structural fragment ion analysis of complex peptide mixtures especially when combined with ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  10. Portable System for Sample Preparation and Differentiation of Pathogens at Strain Level

    SBC: Lynntech Inc.            Topic: CBD04107

    Many believe the greatest threat to our troops and homeland security are attacks using biological weapons. Recent developments of biological warfare agents parallel advances in microbiology, viruses and bacteria can be rendered more lethal through genetic engineering, and many toxins can be mass-produced. However, detecting biological agents is difficult and time consuming because there are thousa ...

    SBIR Phase II 2005 Department of DefenseOffice for Chemical and Biological Defense
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