Award Data

Recently we have observed a massive outbreak of Ebola virus. This family of virus causes a significant bioterrorism threat due to the high levelof mortality, rate of transmissibility and the lack of an approved vaccine or therapy directed against it. The goal of this proposal is to develop,optimize and scale-up a mammalian cell culture-based bioprocess for the rapid manufacture of an antibody-base ...

We propose to create an advanced forensic analysis tool called TheSieve. This tool will use machine learning techniques that can classify files as malicious or benign as well as suggesting files for closer inspection. Built upon custom enhancements to the National Software Reference Library (NSRL), TheSieve will allow forensic investigators to spend theirvaluable time examining the most significan ...

Respiratory equipment has always required the use of a face seal or neck dam to provide good levels of protection. Although proven to beeffective, this approach is constraining when conceiving future integrated systems and can heavily burden the wearer. The development of anew device for lower threat environments, now provides the opportunity to finally remove the rubber off the face. This program ...

The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. Some chemicals also can act directly on the skin including the vesicants sulfur mustard and lewisite. Early and rapid skin decontamination is extremely important following exposure to CWAs and TICs because it de ...

If aquaculture is to become an increasing contributor to the food supply, it is critical that aquaculture feeds become less reliant on marine-derived fishmeal and fish oil as the preferred source of essential proteins and lipids. Not only is the wild fishery from which these products are extracted at maximum sustainable levels of harvest, but also there is increasing concern that these feedstocks ...

The aquaculture industry currently consumes 70 percent of the global production of fish oil and 35 percent of total fishmeal. The salmon and trout fish farming sectors alone consume over one half of the world¿s fish oil. And if fish farming continues to grow at the current rate, then by 2010 the aquaculture industry could well be using all of the world¿s fish oil and half of its fishmeal. The ...

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

A large area (diameter > 200 micrometer) mesa type InGaAs/InAlAs avalanche photodiode with a novel surface passivation technique is proposed for photon counting at eye-safe wavelength of > 1.4 micrometer. The device is expected to exhibit high detection efficiency, low dark count rate with minimal afterpusling, due to the small k factor of InAlAs gain material and the unique mesa sidewall treatmen ...

Concentrated aquatic animal production facilities (CAAP) have recently fallen under new EPA effluent limitations. Compliance with these guidelines creates the opportunity to improve effluent and recycled water quality. Cavitation caused by our FYNAJETS and the collapse of micro-bubbles in water is a low energy, high efficiency method of applying thermal and mechanical stress and chemical oxidati ...

This project entails a comprehensive approach to developing an innovative solution to heads-up display navigation for marine vessels that addresses the required hardware, the sources of raster and vector navigation and marine charting data, and the means to convey these data to watch standers on the bridge in a manner that enhances their performance. During Phase I we identify specific heads-up d ...