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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. ARRAY: A novel polymeric mesh for prophylactic antibiotic protection of cardiac implantable electronic devices

    SBC: 21MedTech LLC            Topic: NHLBI

    PROJECT SUMMARY 21MedTech, LLC is developing the ARRAYTM antibiotic-loaded envelope to address the need for novel methods to tackle rising rates of infections associated with cardiovascular implantable electronic devices (CIEDs). There were 1.5 million CIEDs implanted in 2011 and that number continues to grow. Between 1% and 4% of implantations result in infection, which have potential for severe ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Novel recombinant sensors to study histone ubiquitin signaling

    SBC: Epicypher, Inc.            Topic: 400

    PROJECT SUMMARYMonoubiquitination (Ub) of histones is an important post-translational modification (PTM) that regulates multiple DNA-related processes including DNA replication, transcription, and repair. Aberrant regulation of histone Ub is strongly linked to the pathogenesis of diverse diseases, including cancer, aging, and inflammation. However, the ability to map the distribution and dynamics ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a sensitive method to measure heparan sulfate 6-O-endosulfatase

    SBC: GLYCAN THERAPEUTICS CORPORATION            Topic: 300

    The proposal is aimed to develop a sensitive method to measure the activity of heparan sulfate 6-O-endosulfatase (SULF). SULF is an enzyme that removes the 6-O-sulfo groups from heparan sulfate polysaccharides to modulate the functions of heparan sulfate. Evidence has demonstrated that the level of SULF contributes to the progression of cancers; however, the method that measures the activity from ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Non-invasive molecular imaging tool for rapid, longitudinal assessment of localized metabolic disruptions in animal research and care

    SBC: VIZMA LIFE SCIENCES INC            Topic: 100

    PROJECT SUMMARY The cellular pathophysiology that underlies diseases, such as cancer, cardiovascular disease, and diabetes, begins to change long before disease symptoms become apparent. Moreover, current imaging techniques typically only visualize morphology and structure. Therefore, imaging techniques that can characterize metabolic changes have the potential to detect disease processes long bef ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Development of ultra-efficient antibodies for single cell mapping applications

    SBC: Epicypher, Inc.            Topic: NIAID

    PROJECT SUMMARYHistone post-translational modifications (PTMs) are some of the most widely studied epigenomic factors, and alterations in histone PTM abundance / distribution have been implicated in numerous disease etiologies. Epigenomic mapping of histone PTMs in limited cell populations or single cells (SCs) would provide the opportunity to study the epigenetic landscape of rare and heterogenou ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Developing a Digital Training and Assessment Platform to Disseminate a Successful NIH-Supported College Preparation Model for Diversifying the U.S. Biomedical Workforce

    SBC: MOTHER COMMUNICATIONS CO.            Topic: 500

    Abstract: Developing a Digital Training and Assessment Platform to Disseminate a Successful NIH- Supported College Preparation Model for Diversifying the U.S. Biomedical Workforce This Phase 1 SBIR project will design and test a digital training and assessment platform—HSTA Hatch—to help geographic regions outside West Virginia (WV) establish workforce development programs for grade 9-12 youth ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Arecombinant elastin skin substitute for the treatment of burns

    SBC: INSOMA BIO, INC.            Topic: 300

    Project SummaryThe goal of this project is to optimize and evaluate inSoma Bio’s proprietary recombinant elastin-based biomaterial, Fractomer®, as an effective, low-cost skin grafting support matrix for the treatment of severe burn wounds. Burns are most successfully treated by surgical excision followed by skin grafting; however many patients with severe damage do not have sufficient healthy s ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. The SE-Learn Online Professional Development Platform for Enhanced Social Emotional Learning with Students

    SBC: 3-C Institute for Social Development, Inc.            Topic: 104

    Abstract Considerable evidence demonstrates how children’s social emotional (SE) development plays a significant role in their academic achievement, behavior, and emotional wellbeing. As the scientific base has grown supporting the positive impact of social and emotional learning (SEL) instructional practices, efforts to integrate SEL into academic settings has gained momentum, with teachers inc ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. PA TH2Caregiving: Data-Driven Digital Engagement to Assess and Address the Needs of Family Caregivers

    SBC: PATH2CAREGIVING LLC            Topic: 600

    PROJECT SUMMARY/ABSTRACT Family caregivers are often required to provide post-discharge assistance to individuals with disabling conditions, resulting in strain and negative effects on the caregiver’s health and well-being. While assessing and addressing the needs of family caregivers has been identified as a priority area, there are no comprehensive programs designed to assess a family member ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Mitochondrial-Targeted Therapy for Macular Degeneration

    SBC: ECLIPSE LIFE SCIENCES, INC.            Topic: 100

    SUMMARY Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly. Most AMD cases are the nonexudative (or “dry”) form, which affects up to 200 million patients globally and is comprised of intermediate dry AMD, characterized by formation of sub-retinal pigment epithelium (RPE) deposits called drusen, and geographic atrophy (GA), more advanced disease characte ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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