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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Microcapillary Quartz Sensors for Screening Injectability of High Concentration Protein Formulations

    SBC: Qatch Technologies, LLC            Topic: None

    The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  2. Topic 364: SysMet: Integrative Systems Metabolomics

    SBC: OmicsCraft LLC            Topic: NCI

    Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 377: Enabling Clinical Decision Support for Guideline Based Cancer Symptom Management

    SBC: KLESIS, LLC            Topic: NCI

    The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 374: Targeted and Sustained Release Microparticles for Colon Cancer Chemoprevention

    SBC: Zymeron Corporation            Topic: NCI

    Colorectal Cancer (CRC) is the third most common cancer both in men and women, as well as the second leading cause of cancer deaths with an estimated 135,430 new cases diagnosed and 50,260 deaths for 2017 in the United States. Given the limitations of screening tests and poor prognosis associated with advanced stage colorectal cancer, it would be of great interest in exploring chemoprevention stra ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. The objective of this contract is to develop an HIV latent reservoir assay using a microwell array consumable.

    SBC: Cell Microsystems, Inc.            Topic: NIAID

    A critical remaining challenge toward a true cure for HIV is understanding how latently infected cells evade the immune system and persist as lifelong viral reservoirsOne eradication strategythe so calledshock and killapproachrelies on cell activating compounds to reverse latent infectionand subsequent antiretroviral therapy to eradicate newly activated cellsHoweverthese compounds activate only a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. The purpose of this contract is to develop imprinted polymer resins for the purification of HIV envelope vaccine candidates

    SBC: Zymeron Corporation            Topic: NIAID

    There currently lack diagnostic tools with necessary sensitivity for use in the elimination and post elimination efforts for malaria and other Neglected Tropical DiseasesNTDsMicroscopy and rapid diagnostic testsRDTshave been largely adequate for malaria control and case management but lack the sensitivity to detect low density infectionsAsymptomatic individuals with chronic infection remain reserv ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Ultrasonic Additive Manufacturing of a deep throttling methane injector.

    SBC: T G V Rockets Inc            Topic: T9

    Design and manufacture of a Liquid fuel injector optimized for Ultrasonic Additive Manufacturing. UAM delivers aerospace parts today at 97% of bulk material property and foil laydown rates at speeds significantly better then powder or filament process. UAM has traditionally been applied to 2-D planar surfaces. We will extend UAM into complex geometries and constructs suitable for rocket engine inj ...

    STTR Phase I 2018 National Aeronautics and Space Administration
  8. Integrated Adaptive Route Capability

    SBC: CGH TECHNOLOGIES, INC.            Topic: A3

    This SBIR provides advanced, automated mechanisms for ANSPs and the flight operators to enrich and interact with IFR Preferred Routes in the U.S. National Airspace System (NAS). The FAA’s Instrument Flight Rules (IFR) Preferred Route Program was developed to allow air traffic facilities to identify select routes for use into and out of busy airports and airspace.  We apply automation to ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  9. Habitat ISHM Using Non-Invasive Load Management Analytics

    SBC: MHI Energy Information Solutions, LLC            Topic: H6

    We believe a robust approach to integrated system health management (ISHM) design is the application of redundancy. Redundancy is often thought of in terms of hardware; however, functional, analytic, and information redundancy strategies should also be considered.  Modeling sensor information is invaluable for diagnostics and critical path analysis. A total system approach is an efficient mea ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  10. Smart Fault Management (SFM)

    SBC: TMC Technologies of WV Corp            Topic: S5

    The Phase I of the SBIR “Smart Fault Management” project aims to demonstrate how the fault management process can be innovated by exploiting concepts from a combination of well-established and emerging disciplines such as Bayesian Statistics, GPU-accelerated numerical simulations, Data Science, and Machine Learning that are disrupting the current status quo in many scientific and engin ...

    SBIR Phase I 2018 National Aeronautics and Space Administration

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