List

The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

Colorectal Cancer (CRC) is the third most common cancer both in men and women, as well as the second leading cause of cancer deaths with an estimated 135,430 new cases diagnosed and 50,260 deaths for 2017 in the United States. Given the limitations of screening tests and poor prognosis associated with advanced stage colorectal cancer, it would be of great interest in exploring chemoprevention stra ...

A critical remaining challenge toward a true cure for HIV is understanding how latently infected cells evade the immune system and persist as lifelong viral reservoirsOne eradication strategythe so calledshock and killapproachrelies on cell activating compounds to reverse latent infectionand subsequent antiretroviral therapy to eradicate newly activated cellsHoweverthese compounds activate only a ...

There currently lack diagnostic tools with necessary sensitivity for use in the elimination and post elimination efforts for malaria and other Neglected Tropical DiseasesNTDsMicroscopy and rapid diagnostic testsRDTshave been largely adequate for malaria control and case management but lack the sensitivity to detect low density infectionsAsymptomatic individuals with chronic infection remain reserv ...

We believe a robust approach to integrated system health management (ISHM) design is the application of redundancy. Redundancy is often thought of in terms of hardware; however, functional, analytic, and information redundancy strategies should also be considered.  Modeling sensor information is invaluable for diagnostics and critical path analysis. A total system approach is an efficient mea ...

The Phase I of the SBIR “Smart Fault Management” project aims to demonstrate how the fault management process can be innovated by exploiting concepts from a combination of well-established and emerging disciplines such as Bayesian Statistics, GPU-accelerated numerical simulations, Data Science, and Machine Learning that are disrupting the current status quo in many scientific and engin ...

The proposed research aims to develop a metal matrix composite (MMC) fabric that, when combined with additive manufacturing, will lead to weight reduction, increased structural performance, and reduce fabrication costs of structural components within launch vehicles. The approach focuses on developing a MMC fabric that will be used to selectively reinforce metallic components that are subjected to ...

This project will result in the commercialization of an Intelligent Electronic Speed Controller (IESC) for use on Unmanned Aerial Vehicles (UAVs). The IESC will advance the state-of-the-art of health-state awareness. This will be achieved through the integration of propulsion system health monitoring sensors that - in unison with an Intelligent Rule Set - will be able to monitor system and compone ...

The goal of this Phase II effort is to carry out a series of tasks with the purpose of developing a ground station network that can provide less than 15 minute latency in acquiring data from NOAA space weather assets. These tasks include:  Finalize a set of specifications for ground stations so they can be used to determine the suitability of existing ground stations for the different missions ...