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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Heterogeneous Silicon Photonics OFDR Sensing System

    SBC: Luna Innovations Incorporated            Topic: T8

    Luna will team with Dr. John Bowers of UCSB to continue development of an Optical Frequency Domain Reflectometry (OFDR) system-on-chip using heterogeneous silicon photonics to enable a minimal weight structural health monitoring system. This system-on-chip will be the building block for distributed sensing interrogation systems that are the size of a deck of playing cards. This lightweight, rugged ...

    STTR Phase II 2019 National Aeronautics and Space Administration
  2. Microcapillary Quartz Sensors for Screening Injectability of High Concentration Protein Formulations

    SBC: Qatch Technologies, LLC            Topic: None

    The objective of this SBIR Phase I proposal is to determine the feasibility of viscosity characterization of high concentration protein formulations (HCF) by QATCH’s microcapillary quartz technology. HCFs are non-Newtonian fluids with shear-thinning behavior and they are administered to patients by subcutaneous or muscular injections. The injectability of HCFs depends on the viscosity at high-sh ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  3. Topic 377: Enabling Clinical Decision Support for Guideline Based Cancer Symptom Management

    SBC: KLESIS, LLC            Topic: NCI

    The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 375: Novel Diagnostic Imaging Modality for Monitoring Tumor Responses to a Hyperthermia Immunotherapy (Moonshot)

    SBC: Imago Systems, Inc.            Topic: NCI

    Immunotherapies have been emerging in the past decades as powerful approaches for cancer treatment. However, the immune system is complex, and therapy efficacy is substantially affected by the tumor microenvironment. For this reason, it is currently difficult to visualize tumor response and predict therapeutic efficacy. In this Contract, Imago Systems, Inc., a company with substantial experience i ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 374: Targeted and Sustained Release Microparticles for Colon Cancer Chemoprevention

    SBC: Zymeron Corporation            Topic: NCI

    Colorectal Cancer (CRC) is the third most common cancer both in men and women, as well as the second leading cause of cancer deaths with an estimated 135,430 new cases diagnosed and 50,260 deaths for 2017 in the United States. Given the limitations of screening tests and poor prognosis associated with advanced stage colorectal cancer, it would be of great interest in exploring chemoprevention stra ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Analytical Tools and Approaches for (Multidimensional) Scholarly Research Assessment and Decision Support in the Biomedical Enterprise

    SBC: NET ESOLUTIONS CORPORATION            Topic: NIDA

    NIHthrough NIDAseeks advanced tools that could be broadly used by the life science community and generate results that would be understood by non scientists as well as professional evaluatorsIn Phase Ithe Contractor completed initial development of ERNIEan accessible big data platform integrating multiple data sources and associated methods for quantitative description of research that would facil ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. To develop a nanoSPRi sparing assay.

    SBC: Luna Innovations Incorporated            Topic: NIAID

    Proposes to develop a novelstandardized immune assay that improves monitoring of several biomarkerscytokinesassociated with immunologic pathways of AD with the constraint of having a limited amount of biological samplesThis overall goal is supported by the following program objectivesPhase IDemonstrate proof of concept of nanoSPRiSAas a sensitive and efficient technique in assessing cytokines in h ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. The objective of this contract is to develop an HIV latent reservoir assay using a microwell array consumable.

    SBC: Cell Microsystems, Inc.            Topic: NIAID

    A critical remaining challenge toward a true cure for HIV is understanding how latently infected cells evade the immune system and persist as lifelong viral reservoirsOne eradication strategythe so calledshock and killapproachrelies on cell activating compounds to reverse latent infectionand subsequent antiretroviral therapy to eradicate newly activated cellsHoweverthese compounds activate only a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. The objective of this contract is to develop a novel LBL RNA vaccine that can be administered to induce long-lasting protection against HIV challenge.

    SBC: Luna Innovations Incorporated            Topic: NIAID

    Extensive efforts have gone towards safe and effective vaccines for Human Immunodeficiency VirusHIVprevention and treatmentAlthough many strategies have been attempted for HIV vaccine developmentnone have been successfully establishedOne category of vaccines gaining increased popularity is RNA based vaccineswhich are vaccines containing antigens encoded by RNA and can be delivered by viral or usin ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Innovative Oral Formulations for Anti-Tb Drugs

    SBC: Luna Innovations Incorporated            Topic: NIAID

    The overall objective of this Phase II work plan is to develop a WHO certified fixed dose combinationFDCtroche for treatment of pediatric tuberculosisThis SBIR Phasecontract seeks to finalize development of a fixed dose combinationFDCAnti TB formulation that is stable under ambient conditions foryears and palatable to childrenThe goal of this project is to develop an innovative oral formulation fo ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health

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