Award Data

The goal of this effort is to develop a compact, rugged, electrically efficient, tunable semiconductor laser for the purpose of injection seeding Nd:YAG lasers in NASA lidar systems for remote sensing and atmospheric profiling. A highly stable low power seed laser plays a crucial role in these systems by keeping the high power, Q-switched, Nd:YAG laser at a fixed wavelength and single mode. In add ...

DESCRIPTION (provided by applicant): Atherosclerosis is the underlying cause of most cardiovascular disease and considerable evidence supports the role of hypercholesterolemia as a risk factor for this disease. In preliminary work, we found that tertiary-butyl hydroquinone (TBHQ), at a dose lower than approved for human use, was effective in reducing plasma levels of both total cholesterol and tri ...

DESCRIPTION (provided by applicant): Pretest probability assessment (PTP) plays a pivotal role in the evaluation of pulmonary embolism (PE) in the emergency department (ED) and accurate PTP assessment can modify defensive test-ordering behavior by physicians. However, current methods of PTP assessment produce broad categories of risk that tend to over fit individual patients and seldom obviate tes ...

DESCRIPTION (provided by applicant): The Genomics Revolution and the resultant explosion of knowledge in genomics are shaping our futures. Therefore, it is crucial that knowledge of genomics is broadly disseminated, so that future scientists, educators, policy makers, community leaders, and heads of households can harness the beneficial power of genomic science. Given the indiscriminate impact of ...

DESCRIPTION (provided by applicant): Approximately 50,000 cancer patients a year have recurrent fluid accumulation in the space between their chest wall and lung. This condition is called malignant pleural effusion (MPE). This fluid impairs breathing and worsens the quality of life in these patients. The current treatments are not ideal and include removing the fluid by repetitive needle aspiratio ...

DESCRIPTION (provided by applicant): Septicemia is a medical syndrome characterized by an overwhelming systemic response to infection that can rapidly lead to shock, organ failure and death. In the U.S. septicemia is the 10th leading cause of death overall with over 750,000 cases and 215,000 deaths each year and accounts for $17 billion in annual health care expenditures. Following its release fr ...

DESCRIPTION (provided by applicant): Morphine and other opiate drugs are widely used to treat severe pain but the addiction and side effects they produce often limit their use. The goal of this research is to develop a novel treatment for morphine addiction and toxicity based on an endogenous peptide, glycyl-glutamine (Gly-GIn). Gly-GIn is synthesized in brain from the opioid peptide, beta-endorph ...

DESCRIPTION (provided by applicant): Celiac Sprue is an inherited disease of the intestine caused by ingestion of immunogenic peptides derived from gluten, a class of proteins present in wheat, barley and rye and therefore in many commercially available foods. Symptoms are severe, the only feasible treatment for Celiac Sprue being a strict adherence to a gluten free diet. This work seeks support f ...

Our proposed innovation is to develop neural network (NN) rule extraction technology to a level where it can be incorporated into a software tool, we are calling NNRules, which captures a trained neural network?s decision logic and uses it as a basis for verification and validation (V&V) of the neural network. This formalism has never been attempted. The significance of the NNRules innovation is t ...

DESCRIPTION (provided by applicant): This STTR application requests funds to support the transfer of specific synthetic expertise and methodologies from the Wright Group at Dartmouth College to investigators at Promiliad Biopharma in an effort to reduce Promiliad's REBACS strategy to the level of practice. These efforts will focus on the use of a high-complexity feedstock, nonactic acid, as the p ...