Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. ACE Booster

    SBC: GLOYER-TAYLOR LABORATORIES LLC            Topic: T1

    GTL has been developing a suite of transformational technologies that have the capability to disrupt the traditional launch vehicle paradigm.BHL composite cryotank technology provides a four times improvement over large aluminum iso-grid tanks, offering a 6 percentage point improvement in small stage PMF. Superior Stability Engine is an innovative liquid rocket engine configured to maximize combus ...

    STTR Phase II 2019 National Aeronautics and Space Administration
  2. Rapid Prototyping of Beam-Shaping Metamaterial Antennas via Additive Manufacturing of a Highly Conductive Filament

    SBC: Multi3D LLC            Topic: T8

    This NASA STTR Phase I proposal is aimed at rapid prototyping of antennas beam-shaping with metamaterials and metasurfaces through additive manufacturing of a highly conductive filament - Electrifi. The proposal includes the use of the highly conductive 3D printing filament, which was developed by Dr. Shengrong Ye, the principal investigator at the SBC - Multi3D and is at least 100 times more cond ...

    STTR Phase I 2019 National Aeronautics and Space Administration
  3. Precision Heated Tooling for OOA Curing of Thin-Ply Composites

    SBC: TOUCHSTONE RESEARCH LABORATORY LTD (INC)            Topic: T12

    Thin-ply prepregs offer significant improvements in weight reduction, stiffness and overall mechanical properties over traditional composite laminates. nbsp;Thin plies (lt;0.05 mm/layer) suppress or delay crack initiation in loaded composite structures thereby allowing for manufacturing of lighter, stiffer and more durable composite products. Recent thin-ply prepreg materials, consisting of toughe ...

    STTR Phase I 2019 National Aeronautics and Space Administration
  4. Correction of Splicing Defects in Cystic Fibrosis with Peptide-Oligonucleotide Conjugates and Small Molecule Enhancing Compounds

    SBC: Initos Pharmaceuticals LLC            Topic: NCATS

    ABSTRACT The pathogenesis of Cystic FibrosisCFis caused by mutations in the gene for CFTRa cAMP activated chloride channel that regulates salt and water transport in epithelial tissuesespecially those in the airwaysRecent progress has resulted in small molecule therapeutic agents that partially correct defects in the CFTR protein due to certain mutationsHoweverin a substantial fraction of CF patie ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a predictive moderate throughput assay to screen novel Designer Proline-rich antimicrobial peptide Chaperone protein inhibitors (DPCs) against multi-drug resistant pathogen

    SBC: Arrevus, Inc.            Topic: NIAID

    Multi drug resistantMDRbacterial infections represent a significant threat to public healthIt is estimated that the impact of antibiotic resistance will continue to grow resulting in a global economic burden of $trillion and causingmillion deaths annuallyMany of the therapeutics currently under development represent traditional antibiotic approaches or next generation antibiotics that will likely ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Novel and potent SHIP1 inhibitors for improving hematologic recovery following myelosuppressive therapies

    SBC: Alterna Therapeutics, Inc.            Topic: NHLBI

    ABSTRACT Despite recent advances in targeting cancer cellschemotherapy remains a mainstay of oncologyextending survival and providing cures for many types of cancerHoweverchemotherapy that ablates or suppresses bone marrow cells can be debilitating even when combined with autologous hematopoietic stem cell transplantationHSCTThe treatment causes severe side effects such as anemianeutropenia and th ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Automated CRISPR Screening Using the CellRaft Technology

    SBC: Cell Microsystems, Inc.            Topic: 400

    Project SummaryGenome wide functional genetics has been recently made possible by pooled library based CRISPR Casgene editing technologyBy randomly knocking out thousands of geneslarge scale screens can be conducted for functional geneticsdrug sensitivity and other phenotypesCurrently howeverthis forward genetic approach is largely relegated to live dead screens in mammalian cellsImproving the sop ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Personalized Neural Stem Cell Therapy for Cancer

    SBC: Falcon Therapeutics, Inc.            Topic: NCATS

    PROJECT SUMMARY GlioblastomaGBMis an intractable cancer with an average survival time oftomonthsTreatment options are limited by the infiltration of tumor cells into healthy tissue and the difficulty of delivering effective chemotherapeutics across the blood brain barrierbut engineered neural stem cellsNSCshold great promise as GBM therapies because they selectively migrate to tumor cells and can ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Use of a Designer Proline-rich antimicrobial peptide Chaperone protein inhibitor (DPC) for treating antibiotic resistant pneumonia

    SBC: Arrevus, Inc.            Topic: NIAID

    Project SummaryInfectious disease is the third leading cause of death in the United Statesand hospital acquired infectionsHAIsin particular affectmillion patients annuallyThe most common type of HAI is pneumoniaoften caused by multi drug resistantMDRpathogens such as Staphylococcus aureusPseudomonas aeruginosaKlebsiella pneumoniaeEscherichia coliand Acinetobacter baumanniiRates of antibiotic resis ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. MegaTrans- human transporter machine learning models

    SBC: COLLABORATIONS PHARMACEUTICALS, INC.            Topic: 400

    Summary Being able to predict interactions with important human transporters would be of value to new drug design to avoid compounds that interact with them and cause undesirable side effectsOATP BSLCO Band OATP BSLCO Bare `uptakeandapostransporters largely restricted to the sinusoidal aspect of hepatocytesThey both transport a wide variety of structurally unrelated compoundsincluding members of s ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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