Award Data

The proposed research program will develop a physics-based identification, modeling and risk management infrastructure for aeroelastic transonic flutter and limit-cycle oscillations (LCO). This capability will be built upon high fidelity state-of-the-art theoretical/computational methods as validated and verified by available experimental data bases, and will include (1) rapid flutter boundary det ...

The proposed work aims at developing techniques that will address the current limitations of Cartesian-based Navier-Stokes CFD schemes by exploring three promising methods of implementing improved wall boundary conditions. The three methods are based on: (1) the diamond stencil approach of Delanaye et al., (2) the extrapolation boundary condition work by Marshall and Ruffin, and (3) the Material P ...

DESCRIPTION (provided by applicant): Miniaturized DNA Sequencer for Identification of Microbial Pathogens Abstract. The goal of this project is develop a compact and inexpensive DNA sequencer based on the implementation of sequencing-by-synthesis chemistry on a droplet-based digital microfluidic cartridge. The proposed device would be capable of sequencing 10's to 100's of base pairs using an ine ...

DESCRIPTION (provided by applicant): Newborn screening is currently performed by collecting dried bloodspots from infants and then sending them to a lab for analysis. Lysosomal storage diseases alone number greater than 40 and there is an increasing necessity to screen for a number of disease conditions for which therapies are becoming available. Tandem mass spectrometry is an excellent multiplex ...

DESCRIPTION (provided by applicant): Despite aggressive public health campaigning and strict guidelines for diagnosis and treatment, the estimated incidence of severe hyperbilirubinemia (defined as serum bilirubin levels greater than 99th percentile) is 1:70. Severe hyperbilirubinemia can cause a spectrum of neurologic dysfunction of which kernicterus is the most concerning. Kernicterus manifests ...

The recent emergence of the Silicon Drift detector (SDD), for use in energy dispersive x-ray spectrometry (EDS), has made possible x-ray event streams with count rates as high as 1-10 Mcps. A problem with existing digital signal processing, as applied to SDDs, is the significant presence of coincidence peaks above the x-ray background. These coincidence peaks occur with amplitudes comparable to lo ...

In this NASA Phase I STTR effort, the feasibility of fabricating isolated ridge waveguides in 5% magnesium-doped lithium niobate (5% MgO:LN) will be established. Ridge waveguides in MgO:LN will significantly improve the power handling and conversion efficiency, increase photonic component integration, and be well suited to space based applications. The key innovation in this effort is to combine ...

This SBIR Phase I effort will establish the feasibility of fabricating advanced waveguide structures in potassium titanyl phosphate (KTP) capable of efficiently generating 25 to 40 mW of frequency converted light in the 395 to 480 nm. The key innovation in this effort is to utilize KTP waveguides in a single-pass frequency doubling device to efficiently produce the desired laser wavelengths and po ...

This SBIR Phase I effort proposes to establish the feasibility of developing a compact, high performance laser source for integration into the next generation seed laser system for high stability, multi-wavelength lidar applications such as NASA Langley's HSRL program. Combination of the high performance laser source together with ADVR's integrated Planar Lightwave Circuit (PLC) technology will p ...

This Small Business Innovation Research Phase I project will develop a compact, rugged, rapidly and widely tunable laser based on a quantum cascade diode laser at mid-infrared wavelengths. The key innovation in this effort is the use of an engineered electro-optic tuning element in an external cavity laser to provide control of the laser wavelength through an applied voltage. AdvR has previously ...