Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Clinical Testing of an Insulin Analog

    SBC: THERMALIN DIABETES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The central goal of insulin replacement therapy in the treatment of Type 1 diabetes mellitus (T1DM) is tight control of blood glucose concentration. This Phase I STTR application, submitted by Thermalin Diabetes, Inc., in conjunction with Case Western Reserve University, seeks support for the pre-clinical testing and commercial development of an ultra-stable a ...

    STTR Phase I 2009 Department of Health and Human Services
  2. Radioprotection by use of Topical Lithium Formulations

    SBC: CUMBERLAND PHARMACEUTICALS INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Roughly 500,000 cancer patients are treated with radiotherapy each year. Acute and late sequelae of radiotherapy have a negative impact upon the quality of life of cancer survivors. These sequelae include proctitis, cystitis, esophageal stricture, cutaneous fibrosis plus others. We propose a novel means of preventing the acute and late radiation injury to norma ...

    STTR Phase I 2009 Department of Health and Human Services
  3. Mannan, A Potential Therapeutic for Asthma

    SBC: CUMBERLAND PHARMACEUTICALS INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term goal of this application is to develop mannan derived from Baker's yeast as asthma therapy. The limitations of currently available immunomodulators are their toxicity at higher doses and the lack of beneficial effect on airway smooth muscle (ASM) remodeling and therefore, new adjunctive therapeutics are needed. Initial findings in the P.I.'s labor ...

    STTR Phase I 2009 Department of Health and Human Services
  4. Functional Tissue Engineering for Cartilage Repair

    SBC: Cytex Therapeutics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Degenerative joint diseases such as osteoarthritis remain the source of significant pain and disability, affecting 20 million adults with an economic burden of over 40 billion per year to the United States. While joint replacement is a well-established procedure, its finite life span makes this treatment unacceptable for younger or more active individuals, of ...

    STTR Phase I 2009 Department of Health and Human Services
  5. Fast Spectral Imaging Device For Tumor Margin Mapping

    SBC: Zenalux Biomedical, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The American Cancer Society estimates that a total of 240,430 new breast cancers were diagnosed in 2007 (178,400 new cases of invasive breast cancer, and 62,030 new cases of in situ breast cancer). Approximately 180,000 of these patients undergo breast conserving surgery (BCS), also called lumpectomy. Multiple recent studies show that a staggering 20-70% of the ...

    STTR Phase II 2009 Department of Health and Human Services
  6. Development of ADAM10 Prodomain as a Therapeutic Agent

    SBC: BIOZYME, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Recent cancer therapies have focused on using biologics to target specific signal transduction pathways implicated in the tumor development or progression. For example, recombinant fusion proteins consisting of the extracellular domain of the immunoregluatory proteins and the constant (Fc) domain of immunoglobulin (IgG) represent a growing class of protein ther ...

    STTR Phase I 2009 Department of Health and Human Services
  7. Exercise Stress Cardiac Magnetic Resonance

    SBC: EXCMR, LTD            Topic: N/A

    DESCRIPTION (provided by applicant): Exercise stress testing with imaging is widely used to detect heart disease, but current stress imaging systems suffer from false positives that may lead to unnecessary invasive testing, and false negatives that may miss disease detection until a serious event occurs. Thus, consistently accurate stress imaging remains an important target for technology developm ...

    STTR Phase I 2009 Department of Health and Human Services
  8. A Universal Brain Atlas for Implanting and Managing Deep Brain Stimulators

    SBC: Neurotargeting, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Neurotargeting, LLC proposes to develop the technical support infrastructure as well as clinical tools for a commercial software product that will provide a global service for the medical community involved in deep brain stimulator (DBS) therapy. Specifically, this Phase I study will explore the use of a physiological atlas database that can interface with a nu ...

    STTR Phase I 2009 Department of Health and Human Services
  9. Novel Complementary Therapy for Preterm Infants

    SBC: NOVA-THER TECHNOLOGIES            Topic: N/A

    DESCRIPTION (provided by applicant): Despite improvements in worldwide health and advances in medical practice the incidence of preterm birth continues to rise in virtually every region of the globe and is accounts for nearly 15% of all live births in the United States. Associated with this increased population of very low birth-weight infants are several medical conditions that are both life thre ...

    STTR Phase I 2009 Department of Health and Human Services
  10. The identification of novel negative allosteric modulators of the nicotinic recep

    SBC: Promiliad Biopharma Incorporated            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this Phase I STTR project is to identify novel negative allosteric modulators of the nicotinic acetylcholine receptor. This project seeks to partner the drug discovery technology of the Promiliad Biopharma with the expertise of Professor Dennis McKay to identify novel and subtype selective negative allosteric modulators of the nicotinic acetylcholin ...

    STTR Phase I 2009 Department of Health and Human Services
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